Prozac does not work say scientists

Reply Sat 4 Jul, 2009 09:41 pm
I don't take any drugs of any kind and never would unless for infection (or some related emergency) nonetheless I know people who do!
Prozac, the bestselling antidepressant taken by 40 million people worldwide, does not work and nor do similar drugs in the same class, according to a major review released today.

The study examined all available data on the drugs, including results from clinical trials that the manufacturers chose not to publish at the time. The trials compared the effect on patients taking the drugs with those given a placebo or sugar pill.

When all the data was pulled together, it appeared that patients had improved - but those on placebo improved just as much as those on the drugs.

The only exception is in the most severely depressed patients, according to the authors - Prof Irving Kirsch from the department of psychology at Hull University and colleagues in the US and Canada. But that is probably because the placebo stopped working so well, they say, rather than the drugs having worked better.

"Given these results, there seems little reason to prescribe antidepressant medication to any but the most severely depressed patients, unless alternative treatments have failed," says Kirsch. "This study raises serious issues that need to be addressed surrounding drug licensing and how drug trial data is reported."

The paper, published today in the journal PLoS (Public Library of Science) Medicine, is likely to have a significant impact on the prescribing of the drugs. The National Institute for Health and Clinical Excellence (Nice) already recommends that counselling should be tried before doctors prescribe antidepressants. Kirsch, who was one of the consultants for the guidelines, says the new analysis "would suggest that the prescription of antidepressant medications might be restricted even more".

The review breaks new ground because Kirsch and his colleagues have obtained for the first time what they believe is a full set of trial data for four antidepressants.

They requested the full data under freedom of information rules from the Food and Drug Administration, which licenses medicines in the US and requires all data when it makes a decision.

The pattern they saw from the trial results of fluoxetine (Prozac), paroxetine (Seroxat), venlafaxine (Effexor) and nefazodone (Serzone) was consistent. "Using complete data sets (including unpublished data) and a substantially larger data set of this type than has been previously reported, we find the overall effect of new-generation antidepressant medication is below recommended criteria for clinical significance," they write.

Two more frequently prescribed antidepressants were omitted from the study because scientists were unable to obtain all the data.

Concerns have been raised in recent years about the side-effects of this class of antidepressant. Evidence that they could prompt some young people to consider suicide led to a warning to doctors not to prescribe them for the under-18s - with the exception of Prozac, which was considered more effective than the rest.

In adults, however, the depression-beating benefits were thought to outweigh the risks. Since its launch in the US in 1988, some 40 million people have taken Prozac, earning tens of billions of dollars for the manufacturer, Eli Lilly. Although the patent lapsed in 2001, fluoxetine continues to make the company money - it is now the active ingredient in Sarafem, a pill sold by Lilly for premenstrual syndrome.

Eli Lilly was defiant last night. "Extensive scientific and medical experience has demonstrated that fluoxetine is an effective antidepressant," it said in a statement. "Since its discovery in 1972, fluoxetine has become one of the world's most-studied medicines. Lilly is proud of the difference fluoxetine has made to millions of people living with depression."

A spokesman for GlaxoSmithKline, which makes Seroxat, said the authors had failed to acknowledge the "very positive" benefits of the treatment and their conclusions were "at odds with what has been seen in actual clinical practice".

He added: "This analysis has only examined a small subset of the total data available while regulatory bodies around the world have conducted extensive reviews and evaluations of all the data available, and this one study should not be used to cause unnecessary alarm and concern for patients."
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Type: Discussion • Score: 5 • Views: 1,938 • Replies: 9
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Reply Sat 4 Jul, 2009 09:48 pm
Designer drugs are designed mostly to take the money out of your account.
Reply Sat 4 Jul, 2009 10:28 pm
40 million people worldwide netss a helluva designer price tag, especially in light of the placebo effect having similar efficacy!
Reply Sat 4 Jul, 2009 11:25 pm
I heard that the drug companies, after initially attacking the study, have relented. Seems that they have patented the placebos and are going to sell them for more than the real pills, a kind of a healthy pill that does as much for ya as their original.
Reply Sun 5 Jul, 2009 01:52 am
I guess the price of designer white sugar just went up!
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Reply Sun 5 Jul, 2009 06:12 am
Chumly wrote:
40 million people worldwide netss a helluva designer price tag, especially in light of the placebo effect having similar efficacy!

I think I'll go into business marketing a drug called, Placebo. I bet people would buy it even if they knew what it was (since they are just as effective as "real" medications).
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Reply Sun 5 Jul, 2009 06:20 am
while I do think some medications don't do much of anything, I think the grand scope of this thread is silly.
Reply Sun 5 Jul, 2009 06:33 am
dyslexia wrote:

while I do think some medications don't do much of anything, I think the grand scope of this thread is silly.

I'm not sure how the scope is grand or why it's silly. If a widely prescribed class of drugs is shown to be nearly ineffective, that would seem to rate a mention.
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Reply Sun 5 Jul, 2009 06:41 am
hooked on phonics works for me
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Reply Sun 5 Jul, 2009 10:54 am
I'm gonna take a guess that good old fashioned physical activity (especially if it's goal oriented such as carpentry, automotive, gardening etc) would do more for alleviating the effects of depression than Prozac.

Brave New World
All members of society are conditioned in childhood to hold the values that the World State idealizes. Constant consumption is the bedrock of stability for the World State. Everyone is encouraged to consume the ubiquitous drug, soma, which is probably a historical allusion to a mythical drink of the ancient Aryans. Soma is a hallucinogen that takes users on enjoyable, hangover-free "vacations".
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