First things first, take a look at your resume. Emphasize your Education section by listing classes you took that correlate with the position you're applying for. If you're applying for a cashier job, list any business classes like Typing or Accounting. List classes that you did well in and highlight your GPA if it's over 3.0 but don't list it if it's not. Tailor your resume for different types of positions.
Next, be prepared for an interview. Make sure you know yourself by answering these types of questions from Monster.com:
Basic interview questions:
Tell me about yourself.
What are your strengths?
What are your weaknesses?
Why do you want this job?
Where would you like to be in your career five years from now?
What's your ideal company?
What attracted you to this company?
Why should we hire you?
What did you like least about your last job?
When were you most satisfied in your job?
What can you do for us that other candidates can't?
What were the responsibilities of your last position?
Why are you leaving your present job?
What do you know about this industry?
What do you know about our company?
Are you willing to relocate?
Do you have any questions for me?
Behavioral interview questions:
What was the last project you led, and what was its outcome?
Give me an example of a time that you felt you went above and beyond the call of duty at work.
Can you describe a time when your work was criticized?
Have you ever been on a team where someone was not pulling their own weight? How did you handle it?
Tell me about a time when you had to give someone difficult feedback. How did you handle it?
What is your greatest failure, and what did you learn from it?
How do you handle working with people who annoy you?
If I were your supervisor and asked you to do something that you disagreed with, what would you do?
What was the most difficult period in your life, and how did you deal with it?
Give me an example of a time you did something wrong. How did you handle it?
Tell me about a time where you had to deal with conflict on the job.
If you were at a business lunch and you ordered a rare steak and they brought it to you well done, what would you do?
If you found out your company was doing something against the law, like fraud, what would you do?
What assignment was too difficult for you, and how did you resolve the issue?
What's the most difficult decision you've made in the last two years and how did you come to that decision?
Describe how you would handle a situation if you were required to finish multiple tasks by the end of the day, and there was no conceivable way that you could finish them.
Once you've had your interview, make sure you get the person's contact information to send a follow up Thank You email or letter. Make it a point to send it the day of your interview. If you haven't heard anything in a few days, call the hiring person and ask about the status of your application.
If you don't receive an offer of employment, it's ok to contact the hiring person one last time to inquire how you can improve your performance.
It does take time and patience to find a job, so don't give up. The key is to be prepared.