A FREE "preponderance of evidence":
ERECTILE DYSFUNCTION:
A. DIRECT:
http://www.cirp.org/library/sex_function/fink1/
http://www.cirp.org/library/complications/stinson/
Impotence and adult circumcision. Stinson JM. Journal of the National Medical Association 1973;65:161,179.
http://www.cirp.org/library/complications/stief1/
B. INDIRECT:
http://www.jpost.com/Editions/1999/12/19/Health/Health.441.html
http://news.bbc.co.uk/hi/english/special_report/1998/viagra/newsid_105000/105016.stm
http://news.muzi.com/ll/english/1101338.shtml
http://www.pfizer.com/pfizerinc/investing/annual/earnings/2000Q1earnfin.html
http://news6.thdo.bbc.co.uk/hi/english/special_report/1998/viagra/newsid_95000/95208.stm
http://news.bbc.co.uk/hi/english/world/middle_east/newsid_1182000/1182604.stm
http://www.arabicnews.com/ansub/Daily/Day/980619/1998061903.html
http://news6.thdo.bbc.co.uk/hi/english/despatches/newsid_97000/97479.stm
http://news6.thdo.bbc.co.uk/hi/english/special_report/1998/viagra/newsid_95000/95208.stm
http://news.bbc.co.uk/hi/english/world/middle_east/newsid_1182000/1182604.stm
PLAUSIBLE MECHANISM:
Note, for those unfamilar with the mechanics of erection, it is accomplished withan inflow of NITRIC OXIDE to relax the muscles allowing greater blood flow into the penis.
GROWTH HORMONE ENHANCES REGENERATION OF NITRIC OXIDE YNTHASE-CONTAINING PENILE NERVES AFTER CAVERNOUS NERVE NEUROTOMY IN RATS
GYUNG-WOO JUNG; E. MARTINE SPENCER; TOM F LUE
From the Department of Urology, University of California School of Medicine,San Francisco, California Accepted for publication June 10, 1998.
(LUE) Requests for reprints: Department of Urology, U-575, University ofCalifornia, San Francisco, CA 94143-0738.
THE JOURNAL OF UROLOGY 1998;160:1899-1904
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Abstract
Purpose: As growth hormone has been reported to improve nerve regeneration, we studied the effect of rat growth hormone (GH) on the regeneration of nitric oxide synthase (NOS)-containing penile nerves and the neurons in the pelvic ganglia after unilateral cavernous nerve neurotomy in rats.
Materials and Methods: Male rats were divided into three groups: sham operation (n = 14); unilateral neurotomy of a 5 mm. segment of the cavernous nerve (n = 14) with subsequent injection of buffer solution only; and unilateral neurotomy with GH injection (n = 14). Electrostimulation of the intact cavernous nerve was performed at 1 and 3 months. Nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase staining was used to identify NOS in penile nerve fibers of the mid-shaft segment and in neurons of the pelvic ganglia.
Results: One month after unilateral neurotomy, both the buffer alone and GH-treated groups showed a significant decrease in NOS-containing nerve fibers in the dorsal and intracavernosal nerves on the side of neurotomy. At 3 months, the number of NOS-containing nerve fibers in the buffer alone group did not increase, while the GH-treated group showed a significant increase. In the GH-treated group at 3 months, more NOS-positive neurons in the pelvic ganglia were found on the intact side than on the side of neurotomy (p <0.034), indicating that the regeneration derives from pelvic ganglion neurons on the intact side. Furthermore, electrostimulation in the GH-treated group revealed a greater maximal intracavernosal pressure and a shorter latency period at 3 months than in those given buffer alone.
Conclusions: Our results show that GH injection significantly enhances the regeneration of NOS-containing fibers in the dorsal and intracavernosal nerves after unilateral cavernous nerve injury. We believe that GH administration may present a new and more physiologic approach to the treatment of erectile dysfunction after radical pelvic surgery.