I think it depends upon what kind of self-destruction you speak of.
You mean it in a very literal sense that the notion of self is being destroyed, then you are describing something close to what many eastern religions seek.
However, if you take the societal interpretation of the phrase "self-destruction," then you are left with something more malicious. My interpretation of this phrase, in this context, is that someone is doing behaviors that is detrimental to one's own well-being, such as self-harm.
I would say that the latter is a negative view and the former is a positive one.