Does "the 747" refer to "the 747 amino acids"?

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Context:
“Next, we needed to identify precisely how resveratrol presses on SIRT1’s accelerator,” said Sinclair. The team tested approximately 2,000 mutants of the SIRT1 gene, eventually identifying one mutant that completely blocked resveratrol’s effect. The particular mutation resulted in the substitution of a single amino acid residue, out of the 747 that make up SIRT1. The researchers also tested hundreds of other molecules from the Sirtris library, many of which are far more powerful than resveratrol, against this mutant SIRT1. All failed to activate it.

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http://hms.harvard.edu/news/new-study-validates-longevity-pathway-3-7-13

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Type: Question • Score: 5 • Views: 978 • Replies: 19

[+3] - InfraBlue - 04/10/2013Yes.

View best answer, chosen by oristarA

Yes.

0 Replies

Thank you.

I wonder whether JPB would like to come here to further confirm.

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@oristarA,

HA!

I looked up SIRT1 (sirtuin [silent mating type information regulation 2 homolog] 1) and found that it is a protein, and inferred from that that "747" does refer to the amino acids that it consists of.

What made it ambiguous to me was the reference to "residue," leading me to think that SIRT1 is made up of 747 amino acid residues.

1 Reply

Quote:

. The particular mutation resulted in the substitution of a single amino acid residue, out of the 747 that make up SIRT1.

The use of the word "residue" is really not needed, as the author could have simply said "....of a single amino acid ".

The publication cited isn't really a Journal as we biochemists know them.
Thus sloppy wordage probably is abundant.

2 Replies

@InfraBlue,

InfraBlue wrote:

HA!

I looked up SIRT1 (sirtuin [silent mating type information regulation 2 homolog] 1) and found that it is a protein, and inferred from that that "747" does refer to the amino acids that it consists of.

What made it ambiguous to me was the reference to "residue," leading me to think that SIRT1 is made up of 747 amino acid residues.

Yeah, that's what misled me.

PS. You've given us "homolog] 1". Any misspelling there?

1 Reply

@Miller,

Miller wrote:

Quote:
. The particular mutation resulted in the substitution of a single amino acid residue, out of the 747 that make up SIRT1.

The use of the word "residue" is really not needed, as the author could have simply said "....of a single amino acid ".

The publication cited isn't really a Journal as we biochemists know them.
Thus sloppy wordage probably is abundant.

Good catch.
Thank you.
Thank you both.

0 Replies

@oristarA,

oristarA wrote:

PS. You've given us "homolog] 1". Any misspelling there?

According to the American Heritage Dictionary, it's a variant of homologue. Wikipedia uses it in their article about Sirtuin 1.

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@Miller,

In your opinion, would the sirtuins lessen apoptosis and/or senesence? If yes, would that necessarily be a good thing?

2 Replies

@Foofie,

The slowing of the process of apoptosis will also result in a slowing of the rate at which rogue cancer cells are destroyed. This may not be a good thing, especially for patients receiving any form of chemotherapy.

1 Reply

@Miller,

Miller wrote:

The slowing of the process of apoptosis will also result in a slowing of the rate at which rogue cancer cells are destroyed. This may not be a good thing, especially for patients receiving any form of chemotherapy.

I thought that/read that also. Especially, perhaps, those slow growing cancer cells in a prostate?

As I've read there are a bunch of theories on aging, and nothing has been proven effective for humans, even though some worms and mice benefit from one protocol or another. Obviously there are those that are placing a bet on calorie restriction, and a calorie restriction mimetic would make a lot of money for some company. However, my mitochondria are just not what they used to be. I blame them.

0 Replies

@Foofie,

Nice try, you "two". We know that you're the same person. Smile

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FOOFIE: I agree and I'd question the work on yeast cells. I'm surprised Sinclair is still around.

1 Reply

@Miller,

Miller wrote:

FOOFIE: I agree and I'd question the work on yeast cells. I'm surprised Sinclair is still around.

Thank you for your educated opinion.

2 Replies

@Foofie,

Quote:

Thank you for your educated opinion.

You're not foolin' Setanta, Foofie & Miller, or should I say Foofie/Miller? Smile

2 Replies

@JTT,

Millfoo?

0 Replies

@Foofie,

Foofie wrote:

Miller wrote:

FOOFIE: I agree and I'd question the work on yeast cells. I'm surprised Sinclair is still around.

Thank you for your educated opinion.

You are very welcome.

0 Replies

@JTT,

JTT wrote:

Quote:
Thank you for your educated opinion.

You're not foolin' Setanta, Foofie & Miller, or should I say Foofie/Miller?

Isn't there a current "conspiracy theory" thread that the above should be posted on? It might dovetail nicely with the thread's topic of FDR not knowing about the Japanese attacking Pearl Harbor. Unless of course you want to claim that I knew of the attack, even though I wasn't born yet.

2 Replies

@Foofie,

If Miller knew then you knew. You're not trying to suggest that Setanta, thee Setanta is mistaken, are you?

0 Replies

@Foofie,

Foofie wrote:

JTT wrote:

Quote:
Thank you for your educated opinion.

You're not foolin' Setanta, Foofie & Miller, or should I say Foofie/Miller?

Isn't there a current "conspiracy theory" thread ...

Possibly the one on Shirley Temple...

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Does "the 747" refer to "the 747 amino acids"?

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