@sharonpustejovsky,
I'm night blind, which means I've always been chary of twilight driving situations too, so I always drove from Los Angeles to the near Oregon border in two days, the second day a short fairly early one, for my own safety and others. Besides, it was saner. I virtually always took the prettier route, highway 101, per mapquest, 701 miles - which passed through a lot of gorgeous countryside, ocean side, rolling hills, redwood forest - with plenty of small towns with unique small-town-cafes, in great contrast to shorter and more brutal routes (but not short by much, approx 50 miles). Contrast, not just for the driving serenity, but re cafes and scenery - and also re hours' worth of long haul truckers on your tail even if you were 15 mph over the speed limit on the route I found a bad choice for me.
I'd do most of it the first day, in whichever direction I was going. For ease of generalizing, say, 500 miles, early morning until sunlight worry time in later afternoon, doing these round trips sometimes 2 or 3 times a year.
Since I took the route many times, I explored many just off the highway small towns and developed favorite cafes - at which I would get light meals or snacks.
I could rattle off the names even now. Sometimes I'd sit and eat at the cafes, watch the locals (thinking, the BlueBird cafe) and sometimes I'd pick up a sandwich to go at a grocery place I liked (Oakville Grocery, anyone?) along with either water or some juice. I'd eat half the sandwich, and then sometime later the other half. Wouldn't eat again until I stopped for the night or at home/destination.
Like others, I'd combine gas station stops with peeing and getting some liquid to go. That's when I first discovered vitamin water, which I consider quite a joke but was tasty and nice and cold, or iced tea. In winter, coffee.
My business partner, on the other hand, had no night vision difficulty, was rather bold in life in general, took what I think of as the brutal highway, stopped rarely, and made it in 10.5 hours (estimated 650 miles).
My parents drove across the US several times when I was young. I remember a lot of bits of those trips. I think they were on the less frantic side of the coin, except once in a while, and that is part of why I am now still a fan of travelling.