I had come on line last night in order to post, but felt I'd best re-read (get the flow back in mind) firstly...then, before I knew it had run out of time to post. Oh boy...if I only had more of that elusive notion of '
timefulness.'
I'd like to do two things here,
xris (
as I am especially answering towards him at the moment and other readers as well). One is to amplify in a paraphrased manner one or two questions asked earlier (which had not been responded towards more directly and specifically), and another is to provide only a sample of some studies which give evidences for the conclusion I have been pounding out in this thread (
and elsewhere, regarding this matter, as well). While
there are a number of questions which I had asked which were not more directly and specifically answered towards, I may only put one or two here...
since I hope to amplify and paraphrase (or explain further,
if you will).
The first question was
in post #15 on page 17 and was asking if you had remembered having eaten dinner a couple of days before
that of that particular post. So again, as of the moment that this very post is read, can you report that you recall having eaten dinner two nights before? This is specifically asking for an
episodic memory report. This is of course focusing on the matter of memory formation and retention, and the factors and actors of brain that make such a reportable matter; there will be other memory aspects tied in with the bare episodic long-term memory (LTM) (or non-permanent-in-nature LTM), but here I ask for a report on the episodic portion only.
On
post number 5 of page 18 (and further on too), I had asked about how it can be reported that acknowledged awareness of an object's moving from point A to point B, occurs when all the minicolums in the area of V1 through to MT, of the occipital lobe have died? It has been well demonstrated that V1 activity--
the first level of visual sensory signaling from LGN--is totally preconscious, but informs other cortical (and sub-cortical areas to some extent, quite thinkably). The other areas, however, give us greater degrees of input and direct bearing on what is
spotlighted by the state of having consciousness.
However, if the cells in the MT and area V5 are dead, the state of having consciousness presents with no acknowledged cognition of movement (
the person is aware of not seeing things move...but suddenly appear from either nowhere (seemingly to their mind) or from some other place where the object had simply been 'resting'). If one argues that the cognitive ability to acknowledge, in the first person (and evidence that through actions for the second and third person perspectives), the motion of objects in space and time is intact, even with all those neurons and glia cells being dead, how would we go about doing that?
Now, I will list just a bare sample of the categories of studies which have provided ample evidences for (which act against,
additionally and simultaneously, propositions for consciousness as being of a non-physical something else). For each type of study are listed (and even this is not complete,
xris, but I just don't really have the time, and this is not the medium, and I simply ask for your trust) there will be at least 10 to 20 studies supporting the conclusion and bearing on brain to mind and consciousness relationship, and causation.
The Following Is Only for the Interested:
Sur, M. and Rubenstein, J.L.R. (2005) Patterning and plasticity of the cerebral cortex.
Science 310 (4 Nov): 805~809;
Sakai, K.L. (2005) Language Acquisition and Brain Development.
ibid.:815~819;
Thiebaut de Schotten, M.,
et al. (2005) Direct Evidence for a Parietal-Frontal Pathway Subserving Spatial Awareness in Humans.
Science Vol 309 (30 Sept):2226~2228; (open brain surgery testing and examination)
Samejima, K.
et al. (2005) Representation of Action-Specific Reward Values in the Striatum.
Science Vol 310 (25 Nov): 1337~1340;
Niessing, J.
et al. (2005) Hemodynamic Signals Correlate Tightly with Synchronized Gamma Oscillations.
Science vol 309 (5 Aug):948~951;
Tsao, D. (2006) A Dedicated System for Processing Faces.
Science Vol 314 (6 Oct):72, 73; (winner of the 2006 Eppendorf prize for biology)
Tsao, D.,
et al. (2006) A Cortical Region Consisting Entirely of Face-Selective Cells.
Science Vol 311 (3 Feb):670~674;
Chan, J.R.
et al. (2006) The Polarity Protein Par-3 Directly Interacts with p75 NTR to Regulate Myelination.
Science Vol 314 (3 Nov):832~836;
Summerfield, C.
et al. (2006) Predictive Codes for Forthcoming Perception in the Frontal Cortex.
Science Vol 314 (24 Nov):1311~1314;
Popesco, M.C.,
et al. (2006) Human Lineage-Specific Amplification, Selection, and Neuronal Expression of DUF1220 Domains.
Science Vol 313 (1 Sept):1304~1307;
Nieder, A.,
et al. (2006) Temporal and Spatial Enumeration Processes in the Primate Parietal Cortex.
Science Vol 313 (8 Sept):1431~1435;
Wilson, R.I. (2007) Neural Circuits Underlying Chemical Perception.
Science vol 318 (26 Oct):584, 585; (winner of 2007 Eppendorf prize for biology)
Koechlin, E., and Hyafil, A. (2007) Anterior Prefrontal Function and the Limits of Human Decision-Making.
ibid.:594~598;
Mansouri, F.A.
et al. (2007) Mnemonic Function of the Dorsolateral Prefrontal Cortex in Conflict-Induced Behavioral Adjustment.
Science Vol 318 (9 Nov):987~990;
Reijmas, L.G.
et al. (2007) Localization of a Stable Neural Correlate of Associative Memory.
Science Vol 317 (31 Aug):1230~1233;
Mobbs, D.
et al. (2007) When Fear is Near: Threat Emminence Elicits Prefrontal-Periaqueductal Gray Shifts in Humans.
Science vol 317 (24 Aug):1083~1086;
Huang, L.
et al. (2007) Characterizing the Limits of Human Visual Awareness.
Science vol 317 (10 Aug):823~825;
Depue, B.
et al. (2007) Prefrontal Regions Orchestrate Suppression of Emotional Memories via a Two-Phase Process.
Science Vol 317 (13 July):215~219;
Saalmann, Y.B.
et al. (2007) Neural Mechanisms of Visual Attention: How Top-Down Feedback Highlights Relevant Locations.
Science Vol 316 (15 June):1612~1615;
Pessiglione, M.
et al. (2007) How the Brain Translates Money into Force; A Neuroimaging Study of Subliminal Motivation.
Science Vol 316 (11 May):904~906;
Buschman, T.J. and Miller E.K. (2007) Top-Down Versus Bottom-Up Control of Attention in the Prefrontal and Posterior Parietal cortices.
Scinece Vol 315 (30 Mar):1860~1862;
[and this count ratio sample will continue in the journal Science for 2008~2010, as well]
Hanslmayr, S.,
et al (2009) Anticipatory Signatures of Voluntary Memory Suppression.
J. Neurosci. Vol 29 (March 4):2742~2747;
Mathewson, K.E.,
et al. (2009) To See of Not to See: Prestimulus a
(should be Greek alpha, but no font for that here) Phase Predicts Visual Awareness.
ibid.:2725~2732;
David, S. V.,
et al. (2009) Rapid Synaptic Depression Explains Nonlinear Modulation of Spectro-Temporal Timing in Primary Auditory Cortex by Natural Stimuli.
J. Neurosci. Vol 29 (March 18):3374~3386;
Lehn, H.,
et al. (2009) A Specific Role of the Human Hippocampus in Recall of Temporal Sequences.
ibid.:3475~3484;
Xu, J.,
et al. (2009) mGluR5 Has a Critical Role in Inhibitory Learning.
J. Neurosci. Vol 29 (March 25):3673~3684;
Kraemer, D.J.M.,
et al. (2009) The Neural Correlates of Visual and Verbal Cognitive Styles.
ibid.:3792~3798;
Gallivan, J.P.,
et al. (2009) Is That Within Reach? fMRI Reveals That the Human Superior Parieto-Occipital Cortex Encodes Objects Reachable by the Hand.
J. Neurosci. Vol 29 (April 8): 4381~4391;
Yalachkov, Y.,
et al. (2009) Brain Regions Related to Tool Use and Action Knowledge Reflect Nicotine Dependence.
J. Neurosci. Vol 29 (April 15):4922~4929;
Sterpenich, V.,
et al. (2009) Sleep Promotes the Neural Reorganization of Remote Emotional Memory.
J. Neurosci. Vol 29 (April 22):5143~5152;
Well, I just kind of pulled out a number of issues of the Journal of Neuroscience from 2009 here to do this...but am kind of tired now. Also, when I look at what is left to do even with the other journals...wow...let me get back later with this listing (if there is actual need for it, really) later, with simply an even more direct and impact studies, xris