@dlowan,
I think that there has very likely been very little serious research (i.e., research with a methodology subject to analysis and criticism) on alcohol. When i got out of the army, in which i had been in the medical corps, i worked for a few years in hospitals (until i got sick of prima dona nurses and doctors), and specifically in emergency rooms. Weekends, of course, you're just swamped with drunks who have injured themselves, or with those injured as the result of their or someone else's drunkenness. One of the complaints i heard more than once by ER doctors was the lack of reliable literature on alcohol and its effects--
other than long term, heavy alcohol abuse. There was an article in
The New England Journal of Medicine in the early 1970s about the effect of a 5% fructose solution (IV drip) as opposed to the normal 5% glucose, but that was simply a description of clinical effects, and didn't address the much more interesting topic of how alcohol effects the individual's personality.
Given that alcohol is one of the most destructive drugs known to man, and that it is legal almost everywhere as it has been for thousands of years, and finally, given the vexed questions of drug abuse in our contemporary world, i would hazard a surmise that no one has really ever taken a systematic look a the topic. You can bet Seagram's isn't going to fund the research. As the most commonly abused drug, i'd bet the idea of dissecting it with clinical studies makes too many people uncomfortable.
And we do live in a society with a terrible blind spot. Prospective employers or government agencies often require drug testing before they will employ you--they don't seem to take much interest in one's drinking habits, though, unless and until they glaringly impinge on one's performance of one's duties.