1) Is it wrong/immoral/irresponsible not to vote?
The morality of abstaining from voting can only be measured in the person's other political statements. In other words, I think it is immoral to not vote, but to boast about how thing ought to be.
2) What do you expect of your fellow man, politically speaking(irrespective of partisanship)?
That to some degree, their political mores are congruent with their actions.
3) What kind of a distinction do you personally draw between a protest vote and non-voting?
If a person uses their vote or abstains from voting, when they did manage to identify something they would have voted for, I think they are irresponsible.
In other words, if you vote for McCain because you hate Obama, but you believe in the politics of some third party candidate, you're a part of the problem. Same goes for someone who would vote for Obama, to block McCain, but they'd actually like a third party candidate.
4) How do you feel about someone who shows little/no interest in politics?
Human interest topics and politics are different. I don't care if someone is not into politics, but indifference on the issues (whatever the platform) is a bit frustrating to observe.