farmerman wrote:Well ole Craig, while mining extremophiles may be the one who breaks the code and provides the clues .
I found the extremophiles to be a very exciting development, precisely because they suggest that the more "benign" models aren't necessarily the only models which can account for the rise of life. The undersea vent extremophiles and the many extremophiles in Yellowstone which live not only in extremely hot water, but what might previously have been thought of as chemically hostile environments say it ain't necessarily so in regard to the earlier speculation about what constituted optimal conditions for the formation of replicating molecules which could lead to "life." I think the Yellowstone finds are particularly interesting because you have heat, what once was thought of as chemically hostile environments, and significantly (see below), the clays.
There is a good, short article on extremophiles in Yellowstone here.
Additionally, extremophiles which have been found in lakes and rivers in Antarctica, clearly demonstrating that the possible range of temperatures (never mind the chemical environment) is far greater than previously thought.
There is a good, short article on extremophiles in Ace Lake, Antarctica here.
Finally, extremophiles have been found in toxic waste dumps, showing that life can survive much more chemically harsh environments than would have been thought even a few decades ago.
There is a good, brief article on extremophiles here. The remaining question, as you note, is what trips the trigger from mere chemical replication to what one might call life (i.e., metabolism, reproduction, adaptation through internal change). The extremophiles are excitingly suggestive, but they don't prove that life can
originate in such environments, but only survive there. As yet, we can't say if life can originate in extreme environments, but only that life can adapt to them once established. Nevertheless, the discovery and study of extremophiles does suggest that life is possible in a much greater range of environments than had previously been assumed.
I find the Antarctic extremophiles very suggestive for several reasons. The early sun was not as "bright" billions of years ago as is the case today, and the effect of greenhouse gases would not have been as great. Although there is evidence to as far back as 2.7 byra that there were high CO2 levels, we don't know for certain if that was the case 4 byra. We also cannot be certain what the methane levels were in the earliest days of the planet. Extremophiles suggest that protein formation
might have taken place in the earliest, much hotter conditions when the earth first formed and was cooling. But it cooled, very likely, to a much lower temperature than is now the average, so even if such proteins formed in the initial hot environment, could they have survived the subsequent cold? The Antarctic extremophiles suggest that they might, and more significantly, the Antarctic extremophiles are methanogens, and might have been (if present) an important source of greenhouse gas in the early life of the planet.
Quote:Venters ideas are preciely that , clay minerals set up surface atractions and reactions to exchange hydroxyls and protons and somewhere, sometime, one of those molecules starts using a cell phone.
I once mentioned to you an article i'd read in
Scientific American in the early 70s about the formation and replication of long protein chains in clay tubes. To me, that was significant because it would provide protection in potentially hostile environments for protein chain formation, as well as providing some protection from cosmic radiation. I've been able to follow a good deal of the speculation precisely because the one science i always did well in and understood was chemistry. Sadly, i do not of course retain the level of knowledge and understanding that i did while i was still at university--but i had a good foundation in high school and university, and am not intimidated by technical explanations, which i can, eventually (if not too lazy) understand.
Quote:All in all, however, sadly we arent really very close close(No matter how some web sites spin it). Until theres a huge potential payback in applied biotech, I dont think that theres going to be a rocket pace in the unequivocal understandings of likes origins. Course thats just me, I listen to colleagues kvetching about lack of funding yet everyone wants an answer yesterday.
I'm not dismayed that we aren't close to the answers. It would have been far more exciting to have lived and sailed the seas in the age of discovery than simply to read about it now, centuries later. No useful answers may be found in my lifetime, but that doesn't lessen my excitement or enthusiasm. Columbus did his first expedition on a shoestring, Ferdinand and Isabella had just won a long and expensive war, and had a "take it or leave it" attitude. People would be appalled if they could see a realistic recreation of
Santa Clara (nicknamed
Pinta by the sailors), and consider that dozens of men lived on that little cockleshell for months on a voyage of more three thousand miles, truly sailing off into the unknown. The had no quarters, and slept wherever they could find space, had one cooked meal a day, and at other times, gnawed on ship's biscuit, so long as they weren't scurvy and losing their teeth. Certainly, many of them would not even have been aware that they lived in the dawning decades of a great age which would alter the human world as no other age, even the era of the Mongol hordes, had ever done.
Prince Henry the Navigator sent his little ships out to crawl down the African coast, and although his contribution has been exagerated and glamorized, it remains true that after failing as a military commander (the Moors made mincemeat of the Portugese), he concentrated on exploration, which yeilded handsome profits, and allowed him continue. This all took place before Columbus--Henry was born almost a century before Columbus set out. Five years after Columbus returned from his first voyage (and, significantly he first arrived in the Portuguese Azores on his return, and then made landfall in Europe at Lisbon), Vasco de Gama made his crucial voyage. Like all the previous Portugese expeditions, he hugged the African coast, until he secured an Arab navigator after he learned at Malindi on the east African coast that the Arabs traded with India from African ports. From the time he reached the Cape of Good Hope and turned east and then north, he travelled almost as far up the east African coast as all the other Portuguese navigators had done in 80 years of crawling down the west coast. But at Malindi, he saw an opportunity and took it; no doubt inspired by Columbus' bold voyage, and with his Arab navigator, he boldly struck out across the rough and stormy seas of the Indian Ocean, convinced by local accounts of the Monsoon, that he could successfully sail out of sight of land and reach India. His success lead to the great age of exploration to the east, which made the Portuguese, and later the Dutch and the English, wealthy and powerful out of all proportion to the size and influence of those nations within Europe.
We live in an equally exciting age. Prince Henry, and those he bankrolled for their voyages, moved forward with "baby steps" down the African coast, until enough knowledge and expertise were accumulated for da Gama to take his gamble, which paid off beyond the most sanguine expectations of anyone in Europe. The exploration of the life sciences by today's scientists may be fated to be the same kind of slow, halting advance into a realm of ignorance, the same kind of voyage into an unknown sea. But despite small rewards, and frequent failures and setbacks, the possibility is great that some day, some scientist or group of scientists will be able to use the knowledge which has been accumulated to strike out on their own voyage into the unknown, with the same potential of fabulous discovery and great returns.
It doesn't bother me that we may live at the very beginning of the initially slow and often frustrating and mystifying journey into this great unknown. Unlike so many of the companions of Columbus or da Gama, we know that we live in such an exciting and important "age of discovery." It is a time worth living in, and my excitement, at least, is very real.