Covid Vaccine Informal Poll and Drinking Society

It wasn't her, it was her mother.

Why we struggle to protect the young from conspiracy theorist parents


The inquest into the death of Paloma Shemirani, the daughter of a British conspiracy theorist, was like something out of a TV show.

As it unfolded, the medical world clashed with "Conspiracyland", with experienced doctors questioned in courtrooms by people who believe in medical disinformation.

Paloma Shemirani, a Cambridge University graduate from East Sussex, died in July last year - seven months after being diagnosed with non-Hodgkin lymphoma. She had been told conventional treatment would give her a high chance of survival, but rejected chemotherapy in favour of alternative methods, like juices and coffee enemas.

Paloma's twin brother Gabriel has long pointed the finger at their mother Kate. He strongly believes that Kate's beliefs were behind Paloma's decision to reject chemotherapy.

On Thursday, coroner Catherine Wood said Paloma was "highly influenced" by her mother's beliefs - as well as others including a family friend and her dad. They all advocated the alternative treatment she used.

"The influence that was brought to bear on Paloma... did contribute more than minimally to her death," the coroner said.

The COVID-19 pandemic, which by early January 2025 has resulted in more than 7 million deaths worldwide, including nearly 170 000 in France, has had a devastating impact on global health, reversing the trend of increasing life expectancy observed over the past decade.1 Vaccination has played a central role in mitigating the impact of the COVID-19 pandemic, saving millions of lives globally.2,3 Several ecological studies have reported a significant correlation between higher COVID-19 vaccination coverage and lower all-cause mortality rates.4-7 While the protective effect of vaccines on COVID-19 mortality is well-established,8 concerns remain about long-term vaccine safety.
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Conclusions and Relevance: In this national cohort study of 28 million individuals, the results found no increased risk of 4-year all-cause mortality in individuals aged 18 to 59 years vaccinated against COVID-19, further supporting the safety of the mRNA vaccines that are widely used worldwide.

US Secretary of Health and Human Services Robert F. Kennedy Jr. has criticized the German government for criminal proceedings in connection with the corona pandemic and accused it of disregarding the autonomy of patients. For this reason, he sent a letter to German Health Minister Nina Warken on Friday, he announced on the X platform. He incorrectly gave the minister's surname as "Workin".

In a video attached to the post, he said that he had learned that "more than 1000 German doctors and thousands of their patients" were currently being prosecuted and punished because they had granted exemptions from wearing masks and vaccinations against Covid-19 during the coronavirus pandemic. "The reports from Germany show that the government is sidelining patient autonomy and restricting people's ability to act on their own beliefs when making medical decisions."


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Kennedy Jr. criticizes Germany over corona proceedings
US Secretary of Health and Human Services Robert F. Kennedy Jr. has criticized the German government for criminal proceedings in connection with the corona pandemic and accused it of disregarding the autonomy of patients. For this reason, he sent a letter to German Health Minister Nina Warken on Friday, he announced on the X platform. He incorrectly gave the minister's surname as "Workin".

In a video attached to the post, he said that he had learned that "more than 1000 German doctors and thousands of their patients" were currently being prosecuted and punished because they had granted exemptions from wearing masks and vaccinations against Covid-19 during the coronavirus pandemic. "The reports from Germany show that the government is sidelining patient autonomy and restricting people's ability to act on their own beliefs when making medical decisions."

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In Germany, numerous cases have ended up in court in various federal states, involving allegations of falsification of vaccination certificates or false certificates for exemption from the mask requirement, for example. However, it was not clear from his post exactly which reports the US minister relied on for his accusations and, in particular, where he got the figures quoted from.

Kennedy Jr. is considered a particularly controversial figure in US President Donald Trump's cabinet. In recent years, the nephew of former US President John F. Kennedy has frequently cast doubt on vaccinations, spread conspiracy theories and made a name for himself with strident statements.

Abstract
Background
Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a rare prothrombotic complication that occurs after adenoviral vector–based vaccination against coronavirus disease 2019; in rare cases, it can also occur after natural adenovirus infection. VITT is mediated by platelet-activating antibodies against the highly cationic protein platelet factor 4 (PF4). The underlying inciting antigen trigger and immunopathogenesis remain unknown.

Methods
We used antibody proteomics to determine the amino acid sequences of anti-PF4 antibodies from 21 patients with VITT and sequenced the genes encoding the immunoglobulin light-chain hypervariable region from 100 patients with VITT. To identify an adenoviral trigger, we used the antigen-binding fingerprints of anti-PF4 and anti–adenovirus protein antibodies to identify a shared serum clonotype and subsequently used adenovirus protein peptides and recombinant anti-PF4 VITT antibodies to map the mimicking linear epitope.

Results
Genomic and proteomic profiling of VITT antibodies revealed a shared immunoglobulin light-chain allele, IGLV3-21*02 or *03, harboring a critical somatic hypermutation, K31E. Only antibodies purified against adenoviral core protein VII (pVII) contained anti-PF4 species matching the VITT fingerprint; antibodies against intact virions or other adenoviral proteins did not. Cross-reactive IgGs were mapped to a basic linear epitope on pVII. A pathogenic anti-PF4 VITT antibody, back-mutated to germline (K31), lost its prothrombotic activity in vitro and in vivo and preferentially bound pVII, a finding that directly supported the role of the hypermutation in the antigenic shift from adenovirus pVII to PF4.

Conclusions
The results of our study indicate that VITT occurs when, in persons with immunoglobulin light-chain allele IGLV3-21*02 or *03, a specific somatic hypermutation develops that affects antibodies that recognize a specific epitope on the adenoviral core protein pVII, which results in misdirection of antibody targeting toward PF4. (Funded by Deutsche Forschungsgemeinschaft and others; German Clinical Trials Register number, DRKS00025738; EU Post-Authorization Study Register number, EUPAS45098.)

We found a new coronavirus receptor in human cells ahead of any virus spillover into the human population.
...Giulia Gallo

The virus - Cardioderma cor coronavirus (CcCoV) KY43, or CcCoV-KY43 - can bind to a receptor cell found in the human lung, but testing in Kenya suggests it has not spilled over into the local human population.

Rather than work on ‘live’ viruses, the scientists used a public database of known genetic sequences, Genbank, to select and synthesise alphacoronavirus ‘spike’ proteins, including 27 viruses originally isolated in bats, and screened these against a library of coronavirus receptors found in human cells.

Spike proteins protrude from the surface of coronaviruses, including SARS-CoV-2, and bind to specific receptors on human cells, triggering infection.

Funded largely through UK Research and Innovation’s Biotechnology and Biological Sciences Research Council (BBSRC) and Kenya Government’s National Research Fund, the study brought together UK and Kenyan expertise to show CcCoV-KY43 binds to the human glycoprotein CEACAM6.

Writing in the journal Nature, the team from The Pirbright Institute, the University of Cambridge, the KEMRI-Wellcome Trust Research Programme, the University of York and the National Museums of Kenya say their findings show alphacoronaviruses (alphaCovs) can use various receptors to enter human cells.

“Viral spike proteins are keys that fit into locks (host receptors) to open the door and enter a cell. So far, we have identified one alphaCov receptor. The challenge now is to find the others,” said Professor Stephen Graham in the Department of Pathology at the University of Cambridge, joint senior author of the paper.

“Before our study, it was assumed all alphacoronaviruses used just one of two possible receptors to enter their host, and the only difference was which species they could enter. We now know alphaCovs might use a whole variety of different receptors to open cells,” said Dr Dalan Bailey, Group Leader at the Pirbright Institute and joint senior author of the paper.

“Not only did we find the new coronavirus receptor in human cells ahead of any virus spillover into the human population, but the study was performed using just a piece of the virus (the spike) rather than the whole pathogen, negating the need to import a live virus into the UK," said Dr Giulia Gallo, lead author of the paper who conducted the work at both the Pirbright Institute and the University of Cambridge.

CcCoV-KY43 is found in heart-nosed bats, Cardioderma cor, an ecologically important species found mainly in eastern Africa including in eastern Sudan and northern Tanzania.

The researchers say the zoonotic (animal-to-human) and pandemic potential of alphaCoVs has remained relatively unchartered - to date, only two cellular receptors have been characterized for alphaCoVs.

The work identifies the need for further study in East Africa to better understand the risk from the family of viruses that can use this receptor to enter human cells. This will help scientists to be better prepared for any spillover of the virus into humans in the future, and potentially begin to start developing human vaccines and antivirals. The team wants to apply the same computational technology used in this study to find other potential human pathogens, and also to understand the wider drivers of zoonotic potential.

Graham added: “We hope our findings will help better understand the risk from the family of viruses we identified that can use the human receptor: for example, by mapping the prevalence of the virus in bats and looking to see if it has already spilled over in at-risk populations.”