Running away is dangerous and never ends well. As a 16 year old, you need responsible adults in your life. You are going to need money, safety and advice. Teenagers on their own are often victimized.
There are better solutions that you can try.
- I don't know the details of your situation. If you are in immediate danger of serious physical or sexual abuse, you can go to the police.
- There is almost certainly a counselor at your school. You can talk to them and find out about resources.
- You can Google for "Family Services" in your area and you can call them. They will have resources.
- You can talk to a doctor.
In any of these situations you will be given a case worker who will look after your interest. They will no more about the resources available and the options open to you. You are old enough that you can tell them what is happening and they will believe you.
You should definitely find an adult you can trust, and there are professionals who you can talk to.
Remember that in two years you will be a legal adult... but that these two years are important. It sounds like you know that high school is important, the best way forward is to get in contact with the people who can help you.