Installing SYSTAT 6 for DOS

I have an old license/disks/manuals for SYSTAT 6 for MS-DOS and somc hardware from the same era, such that I could wipe Windows and install MS-DOS 3.3 or 6.22, or conceivably even 7 or 8 from pre-NT versions of Windows. Has anyone else done this, who has tips to offer?

SYSTAT can use up to 16MB, whereas the old PCs and Laptops can hold 256 to 512MB, so I assume a ramdisk is in order for temporary files. I'll also want to accomodate USB disks (flash or hard), the internal CD drive, and a Brother HL-1440 laser printer that has PCL 4 and Postscript Level 2 emulation, and (fortunately) a parallel port.