@FBM,
Hard to explain the effects of something in a vapor that doesn't exist, isn't it.
Nano particles are much smaller than smoke particles, and smoke
particles are way smaller than the
droplets in the vape. The size of the particles is part of the explanation for the minimal adsorption of nicotine in the lungs. The majority of what is adsorbed is by way of the mucus membranes in the mouth, nose, and sinuses. The nicotine in tobacco smoke adsorbed by the lungs crosses the blood/brain barrier in a few seconds; that from the mucus membranes takes around twenty minutes.
This pretty much explains why burning tobacco is so much more satisfying in a nicotine deprived state like early morning. It enters the bloodstream ever so much faster than that which is derived from the mucus membranes.
Honestly, I'm about to collapse the fount of misinformation that this thread is. Any links that don't support the thesis are disparaged. The ones that do support it are - well, missing.