35
   

Mental Decline & Dependency/Coping With Aging Loved Ones

 
 
Swimpy
 
  1  
Reply Tue 12 Feb, 2013 08:19 am
@Walter Hinteler,
May your aunt rest in peace, Walter.
Walter Hinteler
 
  1  
Reply Tue 12 Feb, 2013 10:55 am
@Swimpy,
Thanks, Swimpy.
Walter Hinteler
 
  2  
Reply Wed 20 Feb, 2013 10:58 am
@Walter Hinteler,
The funeral had been one week ago, with just us and my sister and her husband.
They only came minutes before and left with just a "bye" directly afterwards.

Today, I got a letter from my sister's lawyer ...

Done that, been there when mother died. Sad
0 Replies
 
Swimpy
 
  3  
Reply Mon 3 Jun, 2013 01:25 pm
My mother turned 104 today. An amazing achievement.https://fbcdn-sphotos-c-a.akamaihd.net/hphotos-ak-prn2/976791_10200247311601335_1710718954_o.jpg
Walter Hinteler
 
  1  
Reply Mon 3 Jun, 2013 01:48 pm
@Swimpy,
Happy birthday to your mother, Swimpy! (Lovely photo!)
Swimpy
 
  1  
Reply Wed 5 Jun, 2013 02:15 pm
@Walter Hinteler,
Thanks, Walter. We think she's kind of cute, too.
ossobuco
 
  1  
Reply Wed 5 Jun, 2013 02:22 pm
@Swimpy,
Me too.
Swimpy
 
  1  
Reply Wed 5 Jun, 2013 08:07 pm
@ossobuco,
Very Happy
0 Replies
 
ehBeth
 
  1  
Reply Wed 5 Jun, 2013 08:29 pm
@Swimpy,
Wow - happy belated birthday Swimpy's mom!

(the verdict in this house is that she's a cutie pie)
Swimpy
 
  1  
Reply Fri 7 Jun, 2013 02:39 pm
@ehBeth,
Thanks, dahlink!
0 Replies
 
Butrflynet
 
  3  
Reply Fri 5 Jul, 2013 02:04 pm
This is a great article for those of us who are caregivers, as is the entire site.

http://www.alzheimersreadingroom.com/2009/12/communicating-in-alzheimers-world.html
Butrflynet
 
  1  
Reply Mon 14 Oct, 2013 12:56 pm
Ran across this on Facebook and thought I'd share it here:

http://www.independent.co.uk/news/uk/home-news/alzheimers-treatment-breakthrough-british-scientists-pave-way-for-simple-pill-to-cure-disease-8869716.html

Alzheimer’s treatment breakthrough: British scientists pave way for simple pill to cure disease

Historic ‘turning point’ hailed as UK researchers discover how to halt death of brain cells, opening new pathway for future drug treatments

Scientists have hailed an historic “turning point” in the search for a medicine that could beat Alzheimer's disease, after a drug-like compound was used to halt brain cell death in mice for the first time.

Although the prospect of a pill for Alzheimer's remains a long way off, the landmark British study provides a major new pathway for future drug treatments.

The compound works by blocking a faulty signal in brains affected by neurodegenerative diseases, which shuts down the production of essential proteins, leading to brain cells being unprotected and dying off.

It was tested in mice with prion disease - the best animal model of human neurodegenerative disorders - but scientists said they were confident the same principles would apply in a human brain with debilitating brain diseases such as Alzheimer's or Parkinson's.

The study, published today in the journal Science Translational Medicine, was carried out at the Medical Research Council's (MRC) Toxicology Unit at the University of Leicester.

“It's a real step forward,” team leader Professor Giovanna Mallucci told The Independent. “It's the first time a substance has been given to mice that prevents brain disease. The fact that this is a compound that can be given orally, that gets into the brain and prevents brain disease, is a first in itself… We can go forward and develop better molecules and I can't see why preventing this process should only be restricted to mice. I think this probably will translate into other mammalian brains.”

In debilitating brain diseases like Alzheimer's, the production of new proteins in the brain is shut down by a build-up of “misfolded proteins” or amyloids. This build-up leads to an “over-activation” of a natural defence mechanism that stops essential proteins being produced. Without these proteins to protect them, brain cells die off - leading to the symptoms of diseases like Alzheimer's.

The compound used in the study works by inhibiting an enzyme, known as PERK, which plays a key role in activating this defence mechanism. In mice with prion's disease, it restored proteins to protect brain cells “stopping the disease in its tracks”, restoring some normal behaviours and preventing memory loss.

Although the compound also produced significant side effects in mice, including weight loss and mild diabetes, which was caused by damage to the pancreas, Professor Mallucci said it would “not be impossible” to develop a drug that protected the brain without the side effects and that work towards doing so had been “very promising”.

The breakthrough was greeted with excitement by scientists, who nonetheless cautioned that it remained a significant proof of principle and a possible basis for new treatments, rather than a guarantee of an Alzheimer's cure in the near future.

Professor Roger Morris, acting head King's College London's department of chemistry, said: “This is the first convincing report that a small drug, of the type most conveniently turned into medicines, stops the progressive death of neurons in the brain as found, for instance, in Alzheimer's disease. True, this study has been done in mice, not man; and it is prion disease, not Alzheimer's, that has been cured. However, there is considerable evidence that the way neurons die in both diseases is similar; and lessons learned in mice from prion disease have proved accurate guides to attenuate the progress of Alzheimer's disease in patients.”

“From finding the first effective drug in a mouse, to having an effective medicine in man, usually takes decades to bring to fruition, in the very few cases in which it is successful. So, a cure for Alzheimer's is not just around the corner. However, the critical point of principle made by Professor Mallucci's study is that a drug, given orally, can arrest neurodegeneration caused by amyloid in the brain.

”This finding, I suspect, will be judged by history as a turning point in the search for medicines to control and prevent Alzheimer's disease.“

David Allsopp, professor of neuroscience at Lancaster University said that the study had thrown up ”very dramatic and highly encouraging results“, but said that more research was needed to overcome the "problematic side-effects" and to prove the technique would be effective against other disease like Alzheimer's and Parkinson's.

There are currently 800,000 people in the UK with dementia and Alzheimer's disease is the most common cause. The number of people living with the condition is set to break one million by 2021, and represents an enormous health burden for the NHS and the social care system. Parkinson's affect 1 in 500 people and around 127,000 people suffer from the condition.

Dr Eric Karran, director of research at Alzheimer's Research UK, said: "Targeting a mechanism relevant to a number of neurodegenerative diseases could yield a single drug with wide-reaching benefits, but this compound is still at an early stage. It will be important for these findings to be repeated and tested in models of other neurodegenerative diseases, including Alzheimer's disease. While Alzheimer's is the most common form of dementia, other diseases that cause dementia are also characterised by the abnormal build-up of proteins in the brain.

“If this process is also working overtime in these conditions too, targeting it could be a promising avenue for investigation. However, what is true in animals does not always hold true in people and the ultimate test for this compound will be to see whether it is safe and effective in people with these diseases.”
ossobuco
 
  1  
Reply Mon 14 Oct, 2013 01:29 pm
@Butrflynet,
I saw that. Almost gave me chills to read it. Many of us will be long gone if and when that works out, but it's still exciting news.
0 Replies
 
roger
 
  1  
Reply Mon 14 Oct, 2013 02:27 pm
@Butrflynet,
That is a great article. I've had to deal with the exact same situation, so I'll try saying "soon" instead of just reminding her that she has just eaten. It certainly can't work any worse.
0 Replies
 
 

Related Topics

Getting Old Sucks - Discussion by Bi-Polar Bear
Coping, the backside of prime - Discussion by wayne
Caroline's problem?? - Question by gungasnake
What is the oldest age you would like to be alive? - Discussion by BumbleBeeBoogie
Embarrassing and Upsetting Senior Moments - Discussion by Phoenix32890
It's all down hill after 40 - Discussion by martybarker
50 Great Things About Women Over 50 - Discussion by Robert Gentel
What keeps you young? - Question by Seed
 
Copyright © 2021 MadLab, LLC :: Terms of Service :: Privacy Policy :: Page generated in 0.04 seconds on 06/23/2021 at 03:18:21