@memester,
memester;70527 wrote:That is what I was going to look for; direct influence.
but I'm only looking to refute your quoted clarification, not all subsequent modification of it, as one of the modifications has a "hedge" built into it, of unknown height.
I already sense a problem because you use the term "gene regulation" , moving away from "gene expression", in a field where "regulation" has a very specific meaning, usually, and I see you moving freely, equating the two.
I think you're putting far too much emphasis on semantics here. What is being discussed here is the regulation of gene expression. You and I both know this, and it is clear what my argument is. Your emphasis on diction is bordering on being a red herring, or if that is too strong, at least a ignoratio elenchi fallacy.
Quote:The challenge is to show change in gene expression without change in DNA sequence, was it not ?
No. It has been established that the regulation of gene expressions without a change in the underlying DNA sequence of a gene is, by definition, what epigenetics is. The challenge was to show how the environment can
directly influence such regulation. A direct influence, as I am defining it, is an influence that does not travel through any intermediate steps. The environment is known to stimulate certain cellular mechanisms controlling the regulation of gene expression, but it is not clear how the environment can
directly cause such regulation, e.g. a methane molecule entering the cell from the environment and methylating the gene without any sort of assistance.
To make sure I'm clear, a direct influence should be seen as follows:
A ---> B, where A is the cause (environmental stimulation) and B is the effect (regulation of gene expression).
An indirect influence would be:
A ---> B ---> C, where A is the cause (environmental stimulation), B is some intermediate mechanism stimulated by A and C is the regulation of gene expression.