Freep is kinda taken with itself. Autopoiesis is barely a hypothesis with absolutely nothing to evidence it yet. I think that Lynn MArgulis work has stretched the credulity of this slef organizing trait and has copped it to be part of her own theology, that of Gaia. Its quite fashionable in organizational structure to invoke it and almost everyone discounts its merits.
Even MArgulis, in her work of capturing entire genomes from other eukaryotes, kind of begs the subject in that "where did the first eukaryotic models come from"?
I rather like the sense of biochemistry wherein we see that natural affinities can occur by , with certain environmental conditions prevailing, merely screwing with the types of bonds that occur on surfaces of most all organics.
We went through this with fresco about a year ago and I forget if we got anywhere then.