1
   

Disfiguring skin disease plagues Afghanistan

 
 
Reply Tue 8 May, 2007 11:45 am
Yesterday's news:

Spread of disease tied to US combat deployments
Quote:
A parasitic disease rarely seen in United States but common in the Middle East has infected an estimated 2,500 US troops in the last four years because of massive deployments to remote combat zones in Iraq and Afghanistan, military officials said.



Today:

Quote:
Disfiguring skin disease plagues Afghanistan

Tue May 8, 2007
By Robert Birsel

KABUL (Reuters) - The 10-year-old Afghan girl has big eyes, a shy smile and a dark lesion speckled with blood on her right cheek.

http://i18.tinypic.com/4vf2uq0.jpg

The girl has leishmaniasis, a disease caused by a parasite transmitted by a tiny sandfly that can lead to severe scarring, often on the face.

The girl, Sahima, wearing a purple tunic and trousers and pale blue shoes, answers "no" softly when asked if the sore hurts.

But her father is worried about the lesion, the size of a big coin.

"Of course, this doesn't look good," the father, Najibullah, said at a leishmaniasis clinic crowded with children with sores in the Afghan capital, Kabul.

Najibullah said he first noticed a mark on his daughter's face two months ago. "It was a very small dot but it grew and grew. If it grows any more it will cover her whole face."

Leishmaniasis isn't a priority for the government and its aid donors, grappling with shocking rates of infant mortality, tuberculosis, malaria and trauma.

The most common form of the disease is not fatal but it causes untold misery. Victims with scarring on their faces are stigmatised: children are excluded at school and girls often won't be able to find husbands.

Long-neglected by the rich world, the disease is attracting a bit more attention in the West, if not more funds.

Some foreign troops in Afghanistan and Iraq have also been bitten by the sandflies and have developed the disease. NATO saw about 150 cases in Afghanistan in 2005 and about 12 last year, a force spokeswoman said.

NATO camps have been fortified to try to stop the sandflies and soldiers are warned to keep sleeves rolled down, to use insect repellant and to watch for bites.

"DISEASE OF DESTRUCTION"

But it's Afghanistan's poor who are most vulnerable.

Kabul, battered and neglected for years, has the world's worst outbreak of leishmaniasis, health experts say.

"It's out of control, absolutely out of control," said Reto Steiner, a medic with the German Medical Service which helps run the Kabul clinic.

"You won't control it until the sanitation has recovered."

The deep ulcers caused by the parasites will heal if left untreated, but that invariably involves disfigurement and can take many months. That has given rise to one of the diseases many nicknames: saldana, or one-year sore.

Though present in all Afghan cities, it is in Kabul's crowded neighbourhoods that the disease has exploded and spread to hundreds of thousands of people.

"When we have one case in a family, of course, it's not only one case: it will be all the family and even the neighbours," said Health Ministry official Abdullah Fahim.

The sandflies that spread the parasites are carried by animals including dogs and a species of gerbil, as well as people. The insects often breed on waste land and in rubbish.

Although they don't fly well, the insects infest the cracks and crevices in people's homes from where they emerge to bite exposed parts of the body -- noses, chins, cheeks and hands -- as people sleep, from late spring to autumn.

"It's a disease of destruction," said Toby Leslie, a researcher from the London School of Hygiene and Tropical Medicine. "It will thrive in post-war areas and areas where there's poor sanitation, poor community services."

Cutaneous leishmaniasis is not fatal although a less-common form, visceral leishmaniasis, can cause organ failure and death.

"Leishmaniasis is one of the top neglected diseases, certainly outside Africa, and it just doesn't attract the funding that's needed," Leslie said.

TREATMENT, PREVENTION

Doctor Faquir Amin says he's been treating leishmaniasis since the 1960s. Refugees returning from abroad are particularly susceptible as they have no resistance, he said.

"No one's taking care of it. The people are coming, it's crowded, the people are susceptible and the disease is increasing," Amin said at his Kabul clinic. "It is not a killer disease but mentally people suffer. We have to deal with it."

The sores are treated with a course of injections, or cauterized to kill the parasites. Amin's clinic has the only laser cauterizing machine in Afghanistan. Electric cauterizing machines are also effective and much cheaper.

Prevention is also key, experts say.

Bed nets impregnated with insecticide are being distributed to stop malaria and they will also stop sandflies spreading leishmaniasis. But only a few nets are being distributed compared with the number needed.

"The ministry is battling to get funds and no one's interested. It's impossible to get funds," said Health Ministry adviser Kathy Fiekert.

"This is an issue that needs to be addressed."
Source
  • Topic Stats
  • Top Replies
  • Link to this Topic
Type: Discussion • Score: 1 • Views: 484 • Replies: 3
No top replies

 
Walter Hinteler
 
  1  
Reply Tue 8 May, 2007 11:46 am
Quote:
Leishmaniasis drug resistance mechanism exposed

Sanjit Bagchi
26 April 2007
Source: SciDev.Net


Indian researchers have identified a mechanism of drug resistance in the parasites that cause visceral leishmaniasis, and suggest an effective way to reverse it.

The study was published in the April issue of the American Journal of Tropical Medicine and Hygiene.

Shyam Sundar, an author on the study from the Institute of Medical Sciences of Banaras Hindu University, told SciDev.Net that the resistance of the leishmaniasis parasite, Leishmania donovani, to sodium stibogluconate ― a common drug used to treat the disease ― is widespread in India.

The researchers studied leishmaniasis parasites and found that those resistant to sodium stibogluconate had an increased concentration of thiols ― sulphur-containing compounds ― in their cells.

The researchers also identified an enzyme, trypanothione reductase, and a gene, MRPA (multidrug resistance protein A) in the resistant parasites.

Sundar told SciDev.Net that these three factors increased the removal of the drug from the parasite's cell, thus resulting in drug resistance

According to the World Health Organization, India accounts for 50 per cent of global leishmaniasis burden, and rural parts of the region of Bihar account for 90 per cent of Indian cases. Bangladesh, Nepal and Sudan are also affected.

"In the most severely affected villages in Bihar, resistance is so high that stibogluconate can effectively treat only one third of the cases even when its dose is 6−8 times higher," said Sundar.

However, the researchers suggested that resistance can be reversed.

The enzyme glutathione reductase is essential in increasing the concentration of thiols in cells.

"An inhibitor of this enzyme may be used to decrease the thiol level and thus revert the drug resistance," Sundar explained.

Testing these inhibitors on the leishmaniasis parasite is the next step in future research.

Swapan Jana, secretary of the Society for Social Pharmacology ― an Indian nongovernmental organisation ― said, "Leishmaniasis predominantly affects poor people and hence despite the advent of various new drugs, stibogluconate, for its low cost, has importance in this disease."

"This study is impressive, because drug resistance is a big problem with stibogluconate, and this shows a way to revert it," he added.

Reference: American Journal Of Tropical Medicine 76, 681 (2007)
Source
0 Replies
 
Miller
 
  1  
Reply Tue 8 May, 2007 11:57 am
Quote:
Nathan Yang , 42, a civilian from Dorchester, contracted visceral leishmaniasis -- the most serious form of the disease -- most likely during a vacation to Greece last September. Yang, who works for an Internet travel company, said it took Boston doctors more than three months to determine what was causing his night sweats, chills, and low-grade fevers.


Boston Globe
0 Replies
 
Walter Hinteler
 
  1  
Reply Tue 8 May, 2007 12:04 pm
I'm very sorry about this one person. Thanks for emntioning it.


But actually I wanted to point at the hundred thousand in Afghainistan.
And especially the children there.
0 Replies
 
 

Related Topics

 
  1. Forums
  2. » Disfiguring skin disease plagues Afghanistan
Copyright © 2025 MadLab, LLC :: Terms of Service :: Privacy Policy :: Page generated in 0.04 seconds on 01/16/2025 at 07:58:50