Hi Macsm11 (and thanks for the welcome!)
In the first group, it looks like the sequence is reversed, so I reversed 18 to get 81.
In the second group, the differences between the numbers were 2, 20, and 32. I took the differences between those three numbers, which are 18 and 12 and figured that the next appropriate number would be 6. Adding 6 to 32 and then 38 to 97 is how I got 135. I hope I'm not way off base, but it made sense to me!
43 45 65 97
135
2 20 32
38
18 12
6