@oolongteasup,
Number the rats 1, 2, 4, 8. Number the bottles 1-15. On each bottle, write the bottle number as the sum of unique powers of two (e.g. 11 = 1+2+8).
Each rat will get a mixture which consists of liquid from all of the bottles with the rat's number in the sum expression (e.g. rat 4 will get liquid from bottles 4, 5, 6, 7, 12, 13, 14, 15).
After the rat(s) has/have died, add their numbers to get the bottle number that contains the poison.