gungasnake wrote:You need to read up a bit, particularly on the topic of J.B.S. Haldane and the problems which population genetics pose for evoloserism, and the so-called Haldane Dilemma. Five billion years would not be anywhere remotely close to long enough.
If J. B. S. Haldane were alive today I sure he wouldn't provide support to the delimma that you ascribe to his name. Particularly since the main source of the delimma is a consequence of the invalid assumptions that only one gene can be fixed at a time and that no other changes can accumulate until the ongoing one is fixed. The result multiplying the number of generations per fixation by the number of total DNA differences makes no sense.
Problems with Haldane's "cost of natural selection" stemmed from an invalid simplifying assumption in his calculations. He divided by a fitness constant in a way that invalidated his assumption of constant population size, and his cost of selection is an artifact of the changed population size. He also assumed that two mutations would take twice as long to reach fixation as one, but because of sexual recombination, the two can be selected simultaneously and both reach fixation sooner. With corrected calculations, the cost disappears (Wallace 1991; Williams n.d.).
In addition Haldane's paper was published in 1957, and Haldane himself said, "I am quite aware that my conclusions will probably need drastic revision" (Haldane 1957, 523). It is irresponsible not to consider the revision that has occurred in the forty years since his paper was published.
The problem of Haldane's ?'Dilemma' on the other hand really isn't Haldane's it comes from Walter ReMine (1993), who promotes the claim, and adds several more invalid assumptions. His model is contradicted by the following:
The vast majority of differences would probably be due to genetic drift, not selection.
Many genes would have been linked with genes that are selected and thus would have hitchhiked with them to fixation.
Many mutations, such as those due to unequal crossing over, affect more than one codon.
Human and ape genes both would be diverging from the common ancestor, doubling the difference.
ReMine's computer simulation supposedly showing the negative influence of Haldane's dilemma assumed a population size of only six (Musgrave 1999).
References:
1. Haldane, J. B. S., 1957. The cost of natural selection. Journal of Genetics 55: 511-524.
2. Musgrave, Ian, 1999. Weasels, ReMine, and Haldane's dilemma.
http://www.talkorigins.org/origins/postmonth/sep99.html
3. ReMine, Walter J., 1993. The Biotic Message, St. Paul Science, Inc.
4. Wallace, Bruce, 1991. Fifty Years of Genetic Load - An Odyssey. Cornell University Press. See particularly Chapters 5, 6, 8, and 9.
5. Williams. (See above)
Further discussion of Haldane's supposed 'dilemma' can be found at
Population Genetics Made Simple by David Plaistid (it is much too long to cutnpaste here)
BTW Gunge, I'm still waiting to hear how Benedict Arnold could possibly be the first democrat while he was lying in his tomb in London in 1801.
Rap