Your buddy has a particularly nasty critter there - one which generally is accompanied by a few other particularly nasty nasties, all of which more or less hang out together and look out for each other. Removal likely is gonna be pretty involved. Doing it wrong can cripple the machine, even to the point of necessitating a full re-install of Windows, with all the headache and heartache that goes along with that game.
Lets get some basic info, and we'll see what we can do.
What operating system is your buddy running?
When you say your buddy's machine "complains about smitfraud and will not come up", just exactly what does the computer say (word for word)?
Does the desktop look like this?
I suspect your buddy's machine boots, but smitfraud has highjacked the desktop. That can be a real teethgrinder, for sure.
Oh, and a plain old Win98 boot floppy will get you into an XP machine so you can fuss with directories and files - its handy if you know which directories and files to fuss with. The Win XP floppy set consists of 6 disks, different ones for Home and Pro - and then there's the Service Packs to consider - but thats another issue.