I just finished shopping for this and buying one today. Here were my candidates:
Iomega 120 GB Desktop Hard Drive $171.04
Pros: Price, plug and play (like all the others I will link), Norton Ghost software
Cons: Fan noise, no power switch
Iomega 250 GB USB/Firewire Desktop $276.99
Same pros and cons as above, but a lot more space.
Seagate Technology 200 GB USB 2.0 and FireWire External Drive $269.99
This is what I bought, the main pro over the others being the power switch. The main con is that it comes with worse drive backup software.
The page says it's not available but that's not true. I just bought it.
Summary:
The software is not needed, if you have a recent OS (probably anything after 98) it will plug and play. I personally won't install any of the backup software and just use it as an additional drive to hold Able2Know backups and tote files between computers (work/home etc).
The fan noise/power switch issue is probably moot if the drive will not be near your bed when you sleep, or if you don't mind unplugging it.
Hope that helps.