How do you define Time?

Locating the Timekeeping Centers of the Brain

Timing is everything. It comes into play when making split-second decisions like knowing when to stop at a red light, catch a ball or modulate a rhythm when playing the piano.

Researchers Stephen M. Rao, PhD, of the Medical College of Wisconsin, Deborah Harrington, MD, of the Veterans Affairs Medical Center in Albuquerque, and Andrew R. Mayer, also of the Medical College, have now identified the areas in the brain that are responsible for perceiving the passage of time in order to carry out critical everyday functions.

Their study is the first to demonstrate that the basal ganglia (brain tissue involved in motor coordination) and the parietal lobe of the brain are critical areas for this timekeeping system. Their study, published in the March 2001 issue of Nature Neuroscience (Vol. 4, No. 3), questions a long-standing and widely held belief in the scientific community that the cerebellum is the critical structure involved in time perception.

"We are excited that our findings can also have application to better understand some neurological disorders," said Dr. Rao, Professor of Neurology and Neuropsychology at the Medical College and principal investigator for the study. "By identifying the area in the brain responsible for governing our sense of time, scientists can now study defective time perception, which has been observed in patients with Parkinson's disease and Attention Deficit Hyperactivity Disorder (ADHD), two maladies commonly thought to have abnormal function within the basal ganglia."

Making accurate decisions regarding the duration of brief intervals of time - from 300 milliseconds to 10 seconds - is critical to most aspects of human behavior. Contemporary theories of short interval timing assume the existence of a timekeeper system within the brain, yet identifying these brain systems has been elusive and controversial. Using a novel functional magnetic resonance imaging (fMRI) technique that tracks second-by-second changes in brain activity, investigators identified regions within the brain that are critical for this timekeeping system.

Seventeen healthy young men and women volunteers were imaged while being asked to perceive the duration of time between the presentations of two consecutive tones. One second later, two more tones were presented and the participants were asked to make a judgment as to whether the duration between the tones was shorter or longer than the first two tones.

To make sure that the brain systems associated with time perception were clearly identified, two control tasks were given which involved listening to tones or estimating their pitch, but not making judgments about their duration. Using this fast imaging technique, the investigators were able to isolate only those areas of the brain activated during presentation of the first two tones - when subjects are only perceiving and attending to time. Their results conclusively demonstrated that timekeeping functions are governed by the basal ganglia and the right parietal cortex.

Investigators have long suspected, based on indirect evidence, that the basal ganglia might be involved in time perception. The basal ganglia have nerve cells that primarily contain the neurotransmitter dopamine. People with Parkinson's disease have an abnormal reduction in dopamine within the basal ganglia and they commonly experience problems with time perception. These difficulties partially improve when patients are administered a drug that increases dopamine levels in the brain. Defective time perception has also been observed in people with Huntington's disease and ADHD, two disorders commonly thought to have abnormal function within the basal ganglia. Animal studies have also demonstrated the importance of dopamine in timekeeping.

Medical College researchers are currently using this new neuroimaging procedure to better understand how the brain enables dopamine replacement drugs and methylphenidate (Ritalin) to normalize time perception in individuals with Parkinson's disease and ADHD, respectively. Another study being conducted in collaboration with investigators at the University of Iowa, will examine time perception in the early stages of Huntington's disease, prior to the development of the characteristic movement disorder.

The critical role of the parietal lobes in timekeeping was first suggested by co-author Deborah L. Harrington, PhD, Associate Research Professor of Neurology and Psychology at the University of New Mexico in Albuquerque and research scientist at the Veterans Affairs Medical Center. She and her colleagues reported that stroke patients with damage to the parietal cortex on the right but not the left side of the brain experienced impaired time perception. Patients for the study have been drawn from Froedtert Hospital and the Clement J. Zablocki VA Medical Center in Milwaukee. The researchers are also studying adult ADHD patients who have been seen since childhood at the Medical College.

For more information on this topic, see the HealthLink article One in Every Classroom: Kids with ADHD Struggle to Make the Grade.

Article Created: 2001-02-26
Article Updated: 2003-07-15


MCW Health News presents up-to-date information on patient care and medical research by the physicians of the Medical College of Wisconsin.

If all life was instantly erased from the planet (and the rest of the universe for that matter), how long would it take for the earth to travel one more time around the sun? I'm going to go out on a limb and say "about one year".

I have a personal theory that matter is nothing more than condensed spacetime, meaning everything can be broken down into different densities of the same material.

Of course, I have no evidence for that...

That would require 'time.'