rosborne979 wrote:Derevon wrote:The day scientists manage to create life out of dead matter and build a self-aware computer which can understand concepts and contemplate its own existence, I will believe in it, but no sooner.
I'm sure these things will happen. But I'm not sure you'll believe it, even when it does.
Ok, it's already been done. See below.
Copyright © 2002 by the American Association for the Advancement of Science
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Volume 297(5583) 9 August 2002 pp 1016-1018
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Chemical Synthesis of Poliovirus cDNA: Generation of Infectious Virus in the Absence of Natural Template
[Research: Reports]
Cello, Jeronimo; Paul, Aniko V.; Wimmer, Eckard*
Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794-5222, USA.
*To whom correspondence should be addressed. E-mail:
[email protected]
Supporting Online Material:
http://www.sciencemag.org/cgi/content/full/1072266/DC1
Materials and Methods; Fig. S1; References and Notes
26 March 2002; accepted 25 June 2002
Published online 11 July 2002; 10.1126/science.1072266
Include this information when citing this paper.
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Abstract
Full-length poliovirus complementary DNA (cDNA) was synthesized by assembling oligonucleotides of plus and minus strand polarity. The synthetic poliovirus cDNA was transcribed by RNA polymerase into viral RNA, which translated and replicated in a cell-free extract, resulting in the de novo synthesis of infectious poliovirus. Experiments in tissue culture using neutralizing antibodies and CD155 receptor-specific antibodies and neurovirulence tests in CD155 transgenic mice confirmed that the synthetic virus had biochemical and pathogenic characteristics of poliovirus. Our results show that it is possible to synthesize an infectious agent by in vitro chemical-biochemical means solely by following instructions from a written sequence.