You've got a bunch of problems there. For starters, see
this thread, and follow the instructions there for the removal of
"Twaintec", but don't do anything else yet.
Once you've done that, and checked things out on that thread, disable System Restore per the instructions found there, then
use this link to downloadCWShredder. Don't download it to a Temp folder or to your desktop, create a folder for it on you C: drive. Unzip it and run it from there, selecting "Fix", not "Scan Only", the reboot; that will probably fix most of this:
R1 - HKCU\Software\Microsoft\Internet Explorer,SearchURL = http:/ /www.windowws.cc/sp.htm?id=278
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Bar = http:/ /www.windowws.cc/sp.htm?id=278
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http:/ /www.windowws.cc/sp.htm?id=278
R1 - HKCU\Software\Microsoft\Internet Explorer\Search,SearchAssistant = http:/ /www.windowws.cc/sp.htm?id=278
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http:/ /www.meshcomputers.com
O1 - Hosts: 127.0.0.0 localhost
O1 - Hosts: 127.0.0.2 auditmypc.com
O1 - Hosts: 127.0.0.3 boards.cexx.org
O1 - Hosts: 127.0.0.4 bulletproofsoft.net
O1 - Hosts: 127.0.0.5 camtech2000.net
O1 - Hosts: 127.0.0.6 cexx.org
O1 - Hosts: 127.0.0.7 computercops.us
O1 - Hosts: 127.0.0.8 ct7support.com
O1 - Hosts: 127.0.0.9 doxdesk.com
O1 - Hosts: 127.0.0.20 kellys-korner-xp.com
O1 - Hosts: 127.0.0.21 kephyr.com
O1 - Hosts: 127.0.0.22 lavasoft.de
O1 - Hosts: 127.0.0.23 lavasoftusa.com
O1 - Hosts: 127.0.0.24 lurkhere.com
O1 - Hosts: 127.0.0.25 majorgeeks.com
O1 - Hosts: 127.0.0.26 merijn.org
O1 - Hosts: 127.0.0.27 mjc1.com
O1 - Hosts: 127.0.0.28 moosoft.com
O1 - Hosts: 127.0.0.29 mvps.org
O1 - Hosts: 127.0.0.30 net-integration.net
O1 - Hosts: 127.0.0.31 noadware.net
O1 - Hosts: 127.0.0.32 no-spybot.com
O1 - Hosts: 127.0.0.33 onlinepcfix.com
O1 - Hosts: 127.0.0.34 pchell.com
O1 - Hosts: 127.0.0.35 pestpatrol.com
O1 - Hosts: 127.0.0.36 safer-networking.org
O1 - Hosts: 127.0.0.37 secure.spykiller.com
O1 - Hosts: 127.0.0.38 secureie.com
O1 - Hosts: 127.0.0.39 security.kolla.de
O1 - Hosts: 127.0.0.40 spybot.info
O1 - Hosts: 127.0.0.41 spychecker.com
O1 - Hosts: 127.0.0.42 spychecker.com
O1 - Hosts: 127.0.0.43 spycop.com
O1 - Hosts: 127.0.0.44 spyguard.com
O1 - Hosts: 127.0.0.45 spykiller.com
O1 - Hosts: 127.0.0.46 spyware.co.uk
O1 - Hosts: 127.0.0.47 spyware-cop.com
O1 - Hosts: 127.0.0.48 spywareinfo.com
O1 - Hosts: 127.0.0.49 spywarenuker.com
O1 - Hosts: 127.0.0.50 spywareremove.com
O1 - Hosts: 127.0.0.51 spywareremove.com
O1 - Hosts: 127.0.0.52 stopzillapro.com
O1 - Hosts: 127.0.0.53 sunbelt-software.com
O1 - Hosts: 127.0.0.54 thiefware.com
O1 - Hosts: 127.0.0.55 tomcoyote.org
O1 - Hosts: 127.0.0.56 unwantedlinks.com
O1 - Hosts: 127.0.0.57 webattack.com
O1 - Hosts: 127.0.0.58 wilders.org
O1 - Hosts: 127.0.0.59 www.auditmypc.com
O1 - Hosts: 127.0.0.60 www.bulletproofsoft.net
O1 - Hosts: 127.0.0.61 www.cexx.org
O1 - Hosts: 127.0.0.62 www.computercops.us
O1 - Hosts: 127.0.0.63 www.ct7support.com
O1 - Hosts: 127.0.0.64 www.doxdesk.com
O1 - Hosts: 127.0.0.65 www.eblocs.com
O1 - Hosts: 127.0.0.66 www.enigmasoftwaregroup.com
O1 - Hosts: 127.0.0.67 www.free-spyware-scan.com
O1 - Hosts: 127.0.0.68 www.free-web-browsers.com
O1 - Hosts: 127.0.0.69 www.grc.com
O1 - Hosts: 127.0.0.70 www.grisoft.com
O1 - Hosts: 127.0.0.71 www.hackfaq.org
O1 - Hosts: 127.0.0.72 www.hazeleger.net
O1 - Hosts: 127.0.0.73 www.javacoolsoftware.com
O1 - Hosts: 127.0.0.74 www.kellys-korner-xp.com
O1 - Hosts: 127.0.0.75 www.kephyr.com
O1 - Hosts: 127.0.0.76 www.lavasoft.de
O1 - Hosts: 127.0.0.77 www.lavasoftusa.com
O1 - Hosts: 127.0.0.78 www.lurkhere.com
O1 - Hosts: 127.0.0.79 www.majorgeeks.com
O1 - Hosts: 127.0.0.80 www.merijn.org
O1 - Hosts: 127.0.0.81 www.mjc1.com
O1 - Hosts: 127.0.0.82 www.moosoft.com
O1 - Hosts: 127.0.0.83 www.mvps.org
O1 - Hosts: 127.0.0.84 www.net-integration.net
O1 - Hosts: 127.0.0.85 www.noadware.net
O1 - Hosts: 127.0.0.86 www.no-spybot.com
O1 - Hosts: 127.0.0.87 www.onlinepcfix.com
O1 - Hosts: 127.0.0.88 www.pchell.com
O1 - Hosts: 127.0.0.89 www.pestpatrol.com
O1 - Hosts: 127.0.0.90 www.safer-networking.org
O1 - Hosts: 127.0.0.91 www.secureie.com
O1 - Hosts: 127.0.0.92 www.security.kolla.de
O1 - Hosts: 127.0.0.93 www.spybot.info
O1 - Hosts: 127.0.0.94 www.spychecker.com
O1 - Hosts: 127.0.0.95 www.spychecker.com
O1 - Hosts: 127.0.0.96 www.spycop.com
O1 - Hosts: 127.0.0.97 www.spyguard.com
O1 - Hosts: 127.0.0.98 www.spykiller.com
O1 - Hosts: 127.0.0.99 www.spyware.co.uk
O2 - BHO: (no name) - {000020DD-C72E-4113-AF77-DD56626C6C42} - C:\WINDOWS\twaintec.dll
O2 - BHO: (no name) - {549B5CA7-4A86-11D7-A4DF-000874180BB3} - (no file)
O2 - BHO: (no name) - {FDD3B846-8D59-4ffb-8758-209B6AD74ACC} - (no file)
O4 - HKCU\..\Run: [w56dl9imik] C:\WINDOWS\r3zxdkge4g.exe
O14 - IERESET.INF: START_PAGE_URL=http://www.meshcomputers.com
O16 - DPF: {1C78AB3F-A857-482E-80C0-3A1E5238A565} - ms-its:mhtml:file://C:\ss.MHT!http://toolbar.isearch.com/install/00011/chm.chm::/files/initial.cab.
You should now be able to download both
Spybot S&D and
AdAware , but
DO NOT RUN THEIR SEARCHES untill you have opened each one and updated it using its web update function, as explained in the help file for each. When each have been updated, disconnect from the internet, run AdAware, letting it fix anything it finds, then do the same with Spybot. Do not run either untill both have been updated per instructions. It would be good to run both of them while in safemode. That should get you into pretty good shape.