How Did Life Begin? RNA That Replicates Itself Indefinitely Developed For First Time

Specifically, the researchers synthesized RNA enzymes that can replicate themselves without the help of any proteins or other cellular components, and the process proceeds indefinitely. "Immortalized" RNA, they call it, at least within the limited conditions of a laboratory.

More significantly, the scientists then mixed different RNA enzymes that had replicated, along with some of the raw material they were working with, and let them compete in what's sure to be the next big hit: "Survivor: Test Tube."

Remarkably, they bred.

And now and then, one of these survivors would screw up, binding with some other bit of raw material it hadn't been using. Hmm. That's exactly what life forms do ...

When these mutations occurred, "the resulting recombinant enzymes also were capable of sustained replication, with the most fit replicators growing in number to dominate the mixture," the scientists report.

The "creatures" — wait, we can't call them that! — evolved, with some "species" winning out.

"It kind of blew me away," said team member Tracey Lincoln of the Scripps Research Institute, who is working on her Ph.D. "What we have is non-living, but we've been able to show that it has some life-like properties, and that was extremely interesting."

Indeed.