I have to say, I think the relationship between mind and matter is one of the primary metaphysical problems. I think Descartes dualism and Cartesian notions of time and space still dominate much thinking but both are actually in error.
When one decided mind was a completely different kind of substance from matter and could only explain their interaction by resorting to gods intervention, the slow slide to materialism began. First nature lost its soul and now it has lost its mind.
What is mind? What are the fundamental properties of mind? What types of entities or objects possess primitive properties of mind? At what point in the chain of existence or being do the first manifestations of mind appear?
My response is that mind can not be separated from matter. That mind in its most primitive and extensive forms is inherent in and widespread in nature. That perception and experience extend all the way down to the core of nature. That the materialist notion of mind as a rare, emergent and epiphenomena of matter is mistaken. It is this perception of mind which cause one to view the universe as primarily a machine (dead, inert, insensate, mechanical and deterministic). In fact the universe is more like a living organism (enchanted, mysterious, perceptive and experiential. The universe is not composed primarily of material substances but is composed of events (process) which have both mental and material properties or manifestations.