Well, here's where your argument falls down, isn't it? The human race cannot sustains its "present" mutation rate and that projecting "present" conditions into the past, Sanford has shown that our race cannot be more than a thousand generations old.
Surely, you of all people can see the error in Sanford's logic there? Or do I need to spell it out for you?
It's no surprise that most mutations are neutral or detrimental. Scientists know this already:
Marianne Imhof and Christian Schlotterer, Fitness effects of advantageous mutations in evolving Escherichia coli populations, PNAS January 30, 2001 vol. 98 no. 3 1113-1117
What scientists are arguing are that beneficial mutations are selected for. Are you saying this does not happen? Lenski has proved you otherwise with his
E. coli. Or are you saying that the beneficial mutations are far too low?
Well, how low? Can you provide us with evidence to show us how low it really is? Actual evidence and not a book cover?
Not to mention this Sanford's argument seems to be nothing more than a rejuvenated 2nd Law of Thermodynamics argument, which is a rather tired old argument that has been shown to have no merit before.
I'll need more time, however, to come up with a proper reply. Unlike Creationists, I don't accept any old crap that's presented to me and actually go find the actual research papers.
EDIT: Well, that took me less time than I originally thought. At first, I thought you'd actually found some obscure point that scientists had actually overlooked. But a quick search proved me wrong.
Let me give you the URL for a research paper that directly refutes Sanford's claims:
http://nar.oxfordjournals.org/cgi/content/full/28/14/2794
In it, one Dr. Thomas Schneider details that genomes deteriorate in the absence of a selection process, but that when the genomes are subject to a selection process, the information content - defined in terms of Shannon information as described in that paper- tends to a maximum.
So yes, Sanford is correct, if we can assume that for entire history of humankind, there have been no selection pressures on the human race. For all of human history. That is, of course, pure bunkum.