OK, kev ... I assume all you really wanna get rid of is your personal stuff. Prolly most of that is gonna be in "My Documents", "My Pictures", or that sort of "User Folder" in which you've saved documents and spreadsheets and the like. You'll want to empty your "Favorites" folder, and the contents of your e-mail client, your profile, and your address books and calendars.
(on my machines, there's a whole slew of "New Folder 1, New Folder 2, New Folder 3 .... New Folder 21
, and a bunch named "Save This" or "Imprtant" or "Do Not Delete" ... I have no idea what's in most of 'em