W.C. Fields and Mae West appeared in only one movie together --
My Little Chickadee -- and they were in very few scenes together.
Bob and Ray, sadly, appeared in only two movies together. They are great in
Cold Turkey (which, unfortunately, has never been released on DVD), and they're in
Author, Author! (which I've never seen, so I can't comment on it).
George Burns and Gracie Allen had a long movie career in addition to their work in vaudeville and on radio. Often, they were the only good thing in a movie, like in
College Swing and
We're Not Dressing.
And let's not forget
Clark & McCullough or
Wheeler & Woolsey (with the inimitable Edgar Kennedy). What am I saying? How could you forget them? You folks have never even heard of them.