The "Old Testament" is not about history at all. It's about mythology and the rage of dreaming sheep.
The Medes controlled an empire which was not based on Babylon. It was based in the Iranian highlands. Astyages was the last king of the Medes, and he was defeated by Cyrus in 550 BCE. Taking Babylon was just mopping up the mess the Medes left behind, when they had let the Chaldeans return to Babylon. You have zero perspective on history. If it's in your cherished book of fairy tales, then you think it's important. The Egyptians were trying to invade and occupy Mesopotamia, the Assyrian empire was decaying, the Chaldeans were trying to take Babylon from them, the Scythians and the Cimmerians were attacking the Assyrians, and so their empire went into a slow collapse and they could no longer hold onto Babylon. It was at this point that the Medes appear, backed up by their cousins, the Persians.
Babylon fell to the Medes
in 596 BCE. It fell to the Persians in 539 BCE.
As for how many cities which were once capitals of world leading empires became completely uninhabited, the answer is none--not even Babylon. Babylon was never the capital of a world leading empire. There has never been a world leading empire. Again, you lack perspective. Babylon only became uninhabited more than 1500 years after the events you are obsessed with. Babylon has been destroyed more than once, and rebuilt. Most recently, Saddam Hussein was trying to rebuild the city in 1983. However, he got distracted not long after that.
You are so obsessively focused on your idiot "prophecies" that you are unable to see the flow of history which swirled around the city once known as Babylon. If i had a thousand dollars for every two-bit, tin-pot thug who set up a throne in Babylon and called himself the King of a "world-leading" empire, i'd retire to Hawaii.
As for the implications of that stupidity about "world-leading" empires, the capital of the Achaemenid empire was Susa in what is now Iran. It was overrun time and again by Assyrians, Medes, Persians, Greco-Macedonians and eventually by Ali and his Muslim army of holy warriors. Just like Babylon, it was marginalized by the Muslims during their "Islamification" of Persia, and wasted away.
There were cities in the coastal deserts of Peru that "died" so long ago, we don't even know their names. Teotihuacan on the Mexican plateau was once a city of more than 100,000 people, and about 1500 years ago, may have been the sixth largest city in the world. It was a well-known religious center, very important to the people of the region--and it was completely unihabited by a thousand years ago. We don't know who it's people were, what language they spoke and why the city declined.
The city of Carthage was completely destroyed by the Romans, and they even plowed salt into the land around the city to prevent its occupation. Unfortunately for them, Utica sits on a river which silted up, so they were forced to rebuild Carthage, so as to have a reliable port. It certainly was never the capital of a "world leading empire," and for as extensive and rich as the Punic empire became before they went to war with the Romans, they were unable to either defend their empire nor to save their city.
I could go on like this for quite a while, but you've already wasted too much of my time with your obsessive idiocy. If you want to believe in your silly fairy tales about prophecy, help yourself. Don't expect that any well-educated people will take you seriously.