@dirrtydozen22,
I'm more likely to find it amusing than condescending or patronizing, but that probably has to do with my age (over 50) and the contexts that it has happened in.
I'm not out there looking for something to upset me, so it's unlikely that something like "good girl" would bother me. If I were looking to squabble, I'm sure it could set me off.
I don't think it's worth the energy to look for something minor to be upset about.