Most notable in this respect is the very core of the Sun, where the temperature may be 0.1 per cent cooler than the expected 15 million degrees C. Although the discrepancy seems small, it implies that the thermonuclear reactions in the core that power the Sun could be underperforming at present.
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I have heard that stars and planets are themselves living things. Therefore, the presence of life in the universe is obvious. We are simply looking for tiny specs of life such as ourselves.