I don't want to end the topic.
But, when you pick actresses who have made only two or three movies (and had tiny uncredited parts in those films), it is unlikely that anyone would know of them (or possibly even know the other actors in their films) and then this topic becomes nothing more than a boring exercise in using IMDB.
Keep it up and see how many people continue to post in this topic.
James Belushi - Gang related - Dennis Quaid
Dennis Quaid--D.O.A.--Meg Ryan
Meg Ryan - Prelude to a Kiss - Alec Baldwin
Alec Baldwin--The Aviator--Ian Holm
Ian Holm - The Aviator - Cate Blanchett
Cate Blanchett--An Ideal Husband--Minnie Driver
Minnie Driver - Hope Springs - Colin Firth
Colin Firth--Nanny McPhee--Emma Thompson
Emma Thompson - Judas Kiss - Alan Rickman
Alan Rickman--Dogma--Ben Affleck
Ben Afflick--Paycheck--Uma Thurman
Uma Thurman - Be Cool - John Travolta
John Travolta - Swordfish - Hugh Jackman
Hugh Jackman - Swordfish - Halle Berry
Halle Berry - Monster's Ball - Billy Bob Thornton
Halle Berry--Monster's Ball--Billy Bob Thornton
Billy Bob Thornton - Bad News Bears - Marcia Gay Harden