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Titrating Aspirin - solvents?

 
 
Bekaboo
 
Reply Wed 9 Feb, 2005 03:09 pm
I'm titrating aspirin... dissolved in ethanol

Anybody know of a better, or infact a worse solvent for doing this? Thx
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Type: Discussion • Score: 1 • Views: 2,311 • Replies: 3
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Adrian
 
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Reply Wed 9 Feb, 2005 08:03 pm
I think ethanol is about the best solvent for aspirin so there are plenty of worse ones. Hot water works, DMSO works, probably a bunch of variations on the ethanol theme that work as long as they don't react with the aspirin...

I'd stick to ethanol.
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Bekaboo
 
  1  
Reply Thu 10 Feb, 2005 11:40 am
I really ought to clarify that - i'm doing my investigation using ethanol, but i have to write a section on all the stuff i didn't do - e.g. all the solvents that i could have chosen but didn't and why
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Adrian
 
  1  
Reply Thu 10 Feb, 2005 07:55 pm
Other possible solvents and their disadvantages;

Water: It's not a good solvent for aspirin, only about 1g/100g.

Other alcohols: None of them are as good or as cheap as ethanol. If you go to THIS site, scroll down to the results and discussion section and then click on Table 1 of the Thermodynamics of Solvation results you can see the varying solubility of aspirin in methanol, ethanol...through to octanol. Ethanol wins.

Other Organic Solvents: DMSO, ether, chloroform, etc are all harder and more expensive to get than ethanol and a lot of them have special handling and use restrictions. Any of the three above can be nasty if you treat them the wrong way.

Hope that helps.
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