Spysweeper has a good reputation in general, and its latest version integrates antivirus/antispyware functions into a sort of "Security/Privacy Suite" - a move which makes a lot of sense; its something becoming common among security/privacy applications. There's also a stand-alone antispyware-only version for a few bucks less.
One downside to the integrated version is that the antivirus doesn't feature real-time eMail or chat/messaging scanning, though the antivirus/antispyware functions do a pretty good job of intercepting and blocking threats brought in by eMail or chat/messaging clients before they can take root in your system and start screwing things up. Be aware also that with antivirus and antispyware integrated into a single app, scans will take a while - though less overall in most instances than individual antivirus and antispyware scans run independently.
For the price, the integrated version seems to me a decent value, and if you have more than one machine, a 3-user license is only a few bucks more than the single-user license, which could be attractive.
As mentioned, Security/Privacy suites are becoming more common, and certainly are the wave of the future. Though typically a little costlier than an assembly of equivalent stand-alone apps from different vendors, the price differential, all things considered, isn't very significant and the convenience factor of having various functions combined into one app designed to let all functions work together (at least in theory) pretty well balances out any price advantage.
A decent, fairly comprehensive overview of the current state of Privacy/Security suites is available
HERE