Another sign that environmental hormones may adversely affect sexual development is the decline in sperm counts and semen volume in men over the past 50 years. In one study of 14,947 men, sperm count dropped by almost 50% between 1940 and 1990, and the amount of semen the men were able to produce dropped an average of almost 20%. Estrogenic compounds loom as a major problem. They include the organohalogen pesticide DDT and its major metabolite, DDE, which accumulate in body fat and are found in breastmilk;