What if businesses start re-opening and infections/deaths increase?

right no its moor of a statistical thing. As I read farther , before the Spanih flu" disappeared" , it had widened its target bases and became less lethal. Without knowing Id guess that some fact in natural selection was at work (Isolation was practiced later and most of the first victims were the young who coul have rturnd from war and were more freely associating).

Not a clue, but Ill bet some degree of mutations had been at work. They are now only excavating graves to cross sample some available virus by PCR. (The technology has become rather more spcific and sensitive in the last 5 or so yrs)

Cytokine release syndrome (CRS) or cytokine storm syndrome (CSS)

is a form of systemic inflammatory response syndrome (SIRS) that can be triggered by a variety of factors such as infections and certain drugs.[3] It occurs when large numbers of white blood cells are activated and release inflammatory cytokines, which in turn activate yet more white blood cells. CRS is also an adverse effect of some monoclonal antibody drugs, as well as adoptive T-cell therapies.[4][5] Severe cases have been called cytokine storms.[2] When occurring as a result of drug administration, it is also known as an infusion reaction.[1]



Signs and symptoms
Symptoms include fever, fatigue, loss of appetite, muscle and joint pain, nausea, vomiting, diarrhea, rashes, fast breathing, rapid heartbeat, low blood pressure, seizures, headache, confusion, delirium, hallucinations, tremor, and loss of coordination.[4]

Lab tests and clinical monitoring show low blood oxygen, widened pulse pressure, increased cardiac output (early), potentially diminished cardiac output (late), high levels of nitrogen compounds in the blood, elevated D-dimer, elevated transaminases, factor I deficiency and excessive bleeding, higher-than-normal level of bilirubin.[4][6]

Cause
CRS occurs when large numbers of white blood cells, including B cells, T cells, natural killer cells, macrophages, dendritic cells, and monocytes are activated and release inflammatory cytokines, which activate more white blood cells in a positive feedback loop of pathogenic inflammation.[4] Immune cells are activated by stressed or infected cells through receptor-ligand interactions.[7]

This can occur when the immune system is fighting pathogens, as cytokines produced by immune cells recruit more effector immune cells such as T-cells and inflammatory monocytes (which differentiate into macrophages) to the site of inflammation or infection. In addition, pro-inflammatory cytokines binding their cognate receptor on immune cells results in activation and stimulation of further cytokine production.[8] This process, when dysregulated, can be life-threatening due to systemic hyper-inflammation, hypotensive shock, and multi-organ failure.

What I called a cytokine Flood