@kgb61,
Almost every continent has a marine mammal or two that have become adapted to fresh water environments. They often start out as "adventurers" that leave the marine environment and travle up the larger esturaies and then feeding rivers.
Several adaptations that have been studied are the adaptees loss of the ability to extcrete excess saline from their systems. (Im not certain that all of the river dwellers like the AMazon Dolphin have lost this ability).The "dome" , the bulbous mass for echolocation changes due to the sediment load in the new environments. Im not sure how this changes but, in the cases of sound propogation, the echolocation may take a on a loer frequency for greater distance location. Also the "flippers" have modified into longer appendages that can be used for bottom "skipping" .
In essesnce, these are animals that may be returning to lives of their ancestors.
Now there are several marine mammals that have partially adapted to fresh water environments, (a few of these are in the North and S American areas). Dolphins and some whales live parts of their years in fresher water estuaries and then return to the saline waters during migrations.
Id say, and this is a guess, that the biggest obstacles to continuous life in fresh water are mwechanisms for dealing with the salinity changes and also navigating in more turbid wters, as well as having the animals horizon defined by the river cross section when out in the sea, there was little problem with open area navigation.