In addition to the aforementioned, one is not faced with the biases or prejudices relative to typical consumer behaviors. If you are obese, a little person, flatulent, have a Don King hairdo, or all of the above, you may enjoy the comfort of your chaise lounge and conduct business with your website as your storefront, as you're sipping on a Snapple. Also, you open up your virtual doors to the world, not just your immediate market area.
I have a feeling that you know this already. Is there some underlying impetus to this question?