Which are the best off-label medications for severe depression/lack of motivational energy?

I'm researching based off experience, what have been the best off-label medications that helped with chronic fatigue, severe forms of depression--associated with fatigue.
Besides Wellbutrin and other common ADHD stimulants and SSRI & SNRI, I found that Acralion; a derivative from vitamin B or Thiamine, to be surprisingly synergistic with Ritalin.
Also, Provigil helped with fatigue. Piracetam, well, did not really help with fatigue or motivation.
What nootropic, Amino Acid, or off-label medication has helped with any form of depression associated chronic fatigue, lack of motivation, and boost well-being?