Giant cryptic 112

10d is queen back study church house 9 r?s?d???? RESIDENCE (standard cryptic convention is that queen = ER, or Elizabeth Regina. So you have 'ER' and 'is' back(wards) giving 'resi', study = 'den' and church being CE (for Church of England - another cryptic convention). Put the whole lot together for 'residence'

15a Hard grind for the mountaineer? 6 4 u?h?l?w?rk UNHOLY WORK (I think)

23a Even italics show attention 3 t?? TLC (2nd, 4th and 6th letters of 'italics')

40a most women get qualifications in science (= BSc) but a hundred lost (= take away the Roman numeral 'c') reproductive capacities 5 w?m?s WOMBS

15a UPHILL WORK

Doh!

Thank you Cherrie.

Imur. Very much appreciated, the breakdowns are great, I had worked out a little of them but not to get the correct answer, thank you.