That's the way the cookie crumbles
The straw that broke the camels back
The older the buck, the stiffer the horn.
Stupid is as stupid does.
Don't change horses in the middle of the stream
A fool and his money are soon parted
Good things come to those who wait
Good things come in small packages
Never bet against the Yankees or Notre Dame.
Out of the mouths of babes
From your lips to God's ears
Not playing with a full deck
@timur,
I like this saying better than the apple keeps doctor away one
@striedz,
Never know what you're going to get in a box of chocolates.
Do you kiss your mom with that mouth?
What's good for the goose is good for the gander.
Put it where the goats can get it (as in, state something in its simplest terms)