@maizey,
Don't know the first and fourth answers, but the others are:
61A ARIZONAS MONUMENT VALLEY OUTCROP ?ES?
53D GUN BARREL PTOTECTOR T?MTION
TAMPION
145D ANXIOUS DRE?FUL
FRETFUL
138A GUITARIST PICA PE?A
249A GLOBAL TRADE BODY OEC?
OECD
Hopefully cherrie or someone else will see this.
Maizie, you may not know this but our great friend Dutchy is in the final stages of his life. He was a huge help to all puzzlers like you over the years. We will miss him.