Colossus No 145,Cryptic

5 Across. Intrigued as college head enters, strangely defiant, ?a?c??????
8.Down, Remote computer link for airport depot, ??e?i???
9 Down, Do relocate mate in tower above, ??r?????
15Down, Have directions to safe harbour, ?a????
26Across, To begin with, roger, please make changes -or you'll get ill again, ?e?a???
49Down, Homestead yet to include stable, ?t????
61 Acroos, Ms Blanchett, blushing, provided feast
I know there is a lot more than usual , but can't get my head around them because of , I am in hospital, & taking some weird drugs. Thanks for the help & cheers, Barby.