@shirlz,
Thanks for all your help i managed to do a few more myself just a few more to go
73a Romes Ancient Region La-i-m (6)
100a Fruity Smelling Compound is this Es-r- (5)
152a Witty Remark (3,3) Bo- M-t
169a Lariat (4)
179a Fish fin support ray b--i-l (6)
185a Angle between leaf and stalk --b- (4)
200a harassed -atr-ed (7)
220a maintains c-nta-ds (8)
249a Soften -el- (4)
159d To God Latin d--
222d kinswoman -i-ce (5)
251d Heralded -s-e-ed (7)