I think it is normal to feel anguish when we are alone (in the sense of being aware of the fact that there is nobody to help us, support us or cooperate with us). In many senses, a human being is the most useful resource another human being can get.
On the one hand, we may have a feeling that achieving objectives is easier when we cooperate.
On the other hand, we are aware we can deal with other people so that we get resources we can't reach or afford alone.
And, of course, many -if not all- of us are well aware that we can manipulate other people so that they take care of us.
So no people -or at least available people- around means, at least for a regular person, as I am, that the best part of our set of strategies is worthless. Thus the anguish...