How about Milt Pappas? Two outs in the ninth inning, 3-2 count on the batter, and the batter takes the next pitch that plate umpire Bruce Froemming calls a ball, thus ruining Pappas's perfect game. Milt's still pissed about that one.
How about Ernie Shore's near-perfect game, spoiled the other way around? Babe Ruth walked the leadoff hitter, then was ejected for arguing with the umpire. Shore came in, the runner on first was caught stealing, and he retired the next 26 batters.
I was at that game. It was a duel for the ages. David Cone (ex-Yank, 39 years old) was pitching for the Sox and gave up 1 unearned run in the ninth to take the loss. When Jurassic Carl's blooper found the grass in shallow center Fenway erupted like we won the damn World Series.